2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Angiopoietins
  5. Angiopoietin-Like 8

Angiopoietin-Like 8

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Angiopoietin-like proteins (ANGPTLs) are identified as a family of proteins structurally similar to the angiopoietins. Eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. ANGPTLs do not bind to the receptors classically targeted by angiopoietins, Tie-1/2, and have been generally considered orphan ligands. Similar to angiopoietins, ANGPTLs are able to potently regulate angiogenesis.
Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. For example, ANGPTL 2, 3, 4, 6 and 7 are pro-inflammatory factors and regulate cancer progression, while ANGPTL1 inhibits tumor angiogenesis and metastasis.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7506
    ANGPTL8/Angiopoietin-like 8 Protein, Human (HEK293, Fc)

    rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8

    		Human HEK293
    ANGPTL 8 Protein, Human (HEK293, Fc) is a secreted inhibitor of LPL. Angiopoietin-like Protein 8 may function as an important metabolic switch, by forming complexes with ANGPTL3, or with ANGPTL4, in order to direct the flow of energy from triglycerides in blood according to the needs of the body.
  • HY-P700561
    ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His)

    rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8

    		Mouse P. pastoris
    ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is 183 a.a., with molecular weight of 22.5 kDa.
  • HY-P700633
    ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His)

    rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8

    		Mouse E. coli
    ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by E. coli , with C-6*His labeled tag and H40A, Q44A, Q47A inactivating mutations. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His) is 183 a.a., with molecular weight of 21.3 kDa.
Cat. No. Product Name Effect Purity