1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Phosphatase

Phosphatases are a group of hydrolases that catalyze the hydrolysis of a phosphomonoester, removing a phosphate moiety from the substrate. In contrast to kinases, which phosphorylate substrate, phosphatases dephosphorylate the substrate. Phosphorylation is a fundamental and pervasive mechanism widely known to regulate the functions of proteins. Phosphatases and kinases act as regulators of protein reversible phosphorylation in the cell, which constitutes a major form of signaling and an essential mechanism of regulation in all living organisms. Protein phosphatases are the enzymes that hydrolyze phospho-ester bonds in phosphorylated proteins. Eukaryotic protein phosphatases are structurally and functionally diverse enzymes that are represented by three distinct gene families, including the PPPs (phosphoprotein phosphatases), PPMs (metal-dependent protein phosphatases) and PTPs (protein tyrosine phosphatases). PPPs and PPMs dephosphorylate phosphoserine and phosphothreonine residues, whereas the PTPs dephosphorylate phosphotyrosine amino acids.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72822
    ALPI Protein, Human (HEK293, His)

    Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase

    Human HEK293
    ALPI Proteinas, an alkaline phosphatase, effectively hydrolyzes diverse phosphate compounds. ALPI Protein, Human (HEK293, His) is the recombinant human-derived ALPI protein, expressed by HEK293 , with C-His labeled tag. The total length of ALPI Protein, Human (HEK293, His) is 484 a.a., with molecular weight of ~70-80 kDa.
  • HY-P75540
    ACP5 Protein, Mouse (HEK293, His)

    Tartrate-resistant acid phosphatase type 5; TR-AP; TrATPase; T5ap; Trap

    Mouse HEK293
    The ACP5 protein may have a crucial role in bone resorption, particularly in the enzymatic activities involved in breaking down bone tissue. ACP5 is linked to the osteoclastic trap, which has higher affinity for nucleotide tri- and diphosphates. Understanding ACP5's mechanisms in bone resorption and its interactions with nucleotide substrates could offer insights into its role in maintaining bone health. ACP5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ACP5 protein, expressed by HEK293 , with C-His labeled tag. The total length of ACP5 Protein, Mouse (HEK293, His) is 305 a.a., with molecular weight of ~35.8-38 kDa.
  • HY-P76669
    TCPTP Protein, Mouse (sf9, His)

    Tyrosine-protein phosphatase non-receptor type 2; MPTP; PTPN2

    Mouse Sf9 insect cells
    TCPTP is a non-receptor tyrosine-specific phosphatase that regulates multiple signaling pathways by dephosphorylating proteins such as INSR, EGFR, CSF1R, PDGFR, JAK, Src kinase and STAT. TCPTP acts in the nucleus and cytoplasm to regulate hematopoiesis, inflammation, cell proliferation, differentiation, and glucose homeostasis. TCPTP Protein, Mouse (sf9, His) is the recombinant mouse-derived TCPTP protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TCPTP Protein, Mouse (sf9, His) is 313 a.a., with molecular weight of ~42 kDa.
  • HY-P7887
    CD45 Protein, Human (552a.a, HEK293, His)

    rHuReceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C

    Human HEK293
    CD45 Protein, Human (HEK 293, His) is a type 1 transmembrane protein tyrosine phosphatase (PTPase) expressed by all the haematopoietic stem cells (HSCs) except that of erythrocytes and platelets.
  • HY-P700394
    ALPI Protein, Human (HEK293, N-His)

    Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase

    Human HEK293
    ALPI Proteinas, an alkaline phosphatase, effectively hydrolyzes diverse phosphate compounds. ALPI Protein, Human (HEK293, N-His) is the recombinant human-derived ALPI protein, expressed by HEK293, with N-10*His labeled tag. The total length of ALPI Protein, Human (HEK293, N-His) is 484 a.a., with molecular weight of 55.2 kDa.
  • HY-P700410
    ENPP3 Protein, Human (HEK293, His)

    E-NPP 3; NPP3; PD-Ibeta; NPPase; ENPP3; PDNP3; CD203c; B10; gp130RB13-6

    Human HEK293
    ENPP3 is a hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP, and CTP, and plays a key role in immune regulation. It modulates mast cell and basophil responses during inflammation and chronic allergic phases by eliminating extracellular ATP, a trigger for inflammatory cytokine release. ENPP3 Protein, Human (HEK293, His) is the recombinant human-derived ENPP3 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ENPP3 Protein, Human (HEK293, His) is 828 a.a., with molecular weight of ~116 kDa.
  • HY-P7884
    CD45 Protein, Mouse (HEK293, His)

    rMuReceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C

    Mouse HEK293
    CD45/PTPRC Protein, Mouse (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. CD45 is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes. PTPRC is an essential regulator of T and B cell antigen receptor-mediated activation.
  • HY-P72916
    CD45 Protein, Mouse (HEK293, Fc)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Mouse HEK293
    The CD45 protein is a multifunctional member of the protein tyrosine phosphatase family with heparan sulfate proteoglycan and heparin binding activity as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecular metabolic processes, and signal transduction regulation. CD45 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD45 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD45 Protein, Mouse (HEK293, Fc) is 400 a.a., with molecular weight of ~130 kDa.
  • HY-P75561
    ACP5 Protein, Human (HEK293, His)

    Tartrate-resistant acid phosphatase type 5; TR-AP; TrATPase; T5ap; Trap

    Human HEK293
    The ACP5 protein actively dephosphorylates osteopontin and bone sialoprotein. Its upregulated expression in pathological conditions like Gaucher and Hodgkin diseases, hairy cell, B-cell, and T-cell leukemias suggests a potential association with these diseases. This underscores ACP5's relevance in diverse pathological states, indicating its role in modulating pathways related to bone health and hematopoietic system disorders. ACP5 Protein, Human (HEK293, His) is the recombinant human-derived ACP5 protein, expressed by HEK293 , with C-His labeled tag. The total length of ACP5 Protein, Human (HEK293, His) is 299 a.a., with molecular weight of ~35 kDa.
  • HY-P77358
    ENPP-7 Protein, Human (HEK293, His)

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; NPP-7; Alk-Smase

    Human HEK293
    The ENPP-7 protein is a choline-specific phosphodiesterase that plays multiple roles in sphingomyelin digestion, ceramide formation, and fatty acid absorption in the gastrointestinal tract. It hydrolyzes sphingomyelin, releases ceramide and phosphocholine, and promotes the breakdown of sphingomyelin. ENPP-7 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-7 protein, expressed by HEK293 , with C-His labeled tag. The total length of ENPP-7 Protein, Human (HEK293, His) is 418 a.a., with molecular weight of ~50-70 kDa.
  • HY-P78196
    CD45 Protein, Human (Biotinylated, HEK293, His-Avi)

    L-CA; CD45; T200; PTPRC; B220; CD45R; GP180; LCA; LY5; EC 3.1.3.48

    Human HEK293
    Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. CD45 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD45 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of CD45 Protein, Human (Biotinylated, HEK293, His-Avi) is 391 a.a., with molecular weight of 80-110 kDa.
  • HY-P7880
    Alkaline Phosphatase/ALPL Protein, Human (HEK293, His)

    rHuAlkaline phosphatase, tissue-nonspecific isozyme/ALPL, His; Alkaline Phosphatase; Tissue-Nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL

    Human HEK293
    Alkaline Phosphatase/ALPL Protein, Human (HEK 293, His) is a cell-surface homodimeric phosphohydrolase that is richly expressed in the skeleton, liver, kidney and developing teeth.
  • HY-P700395
    ALPI Protein, Rat (HEK293, His)

    Intestinal-type alkaline phosphatase; IAP; ALPI; Alkaline Phosphatase

    Rat HEK293
    The ALPI protein, an alkaline phosphatase enzyme, hydrolyzes phosphate compounds, demonstrating enzymatic activity in breaking down different phosphate molecules. ALPI Protein, Rat (HEK293, His) is the recombinant rat-derived ALPI protein, expressed by HEK293, with N-10*His labeled tag. The total length of ALPI Protein, Rat (HEK293, His) is 491 a.a., with molecular weight of 55.9 kDa.
  • HY-P700438
    ENPP3 Protein, Macaca fascicularis (HEK293, His)

    E-NPP 3; NPP3; PD-Ibeta; NPPase; ENPP3; PDNP3; CD203c; B10; gp130RB13-6

    Cynomolgus HEK293
    ENPP3 is a hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP, and CTP, and plays a key role in immune regulation. It modulates mast cell and basophil responses during inflammation and chronic allergic phases by eliminating extracellular ATP, a trigger for inflammatory cytokine release. ENPP3 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived ENPP3 protein, expressed by HEK293 , with N-10*His labeled tag. The total length of ENPP3 Protein, Macaca fascicularis (HEK293, His) is 829 a.a., with molecular weight of ~120 kDa.
  • HY-P7487
    Alkaline Phosphatase/ALPP Protein, Human (HEK293, His)

    rHuAlkaline Phosphatase, His; ALPP; PLAP; ALP; AKP2; Alkaline Phosphatase

    Human HEK293
    ALPP Protein, Human (HEK293, His) is a ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values.
  • HY-P70167
    ENPP-2 Protein, Human (HEK293, His)

    rHuEctonucleotide phosphodiesterase family member 2/ENPP-2, His ; ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2

    Human HEK293
    The ENPP-2 protein catalyzes the hydrolysis of lysophospholipids (especially lysophosphatidylcholine) to produce the signaling molecule lysophosphatidic acid (LPA). It also acts on sphingosine phosphocholine to produce sphingosine 1-phosphate, which affects cell movement. ENPP-2 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ENPP-2 Protein, Human (HEK293, His) is 828 a.a., with molecular weight of 100-120 kDa.
  • HY-P71150
    DUSP3 Protein, Human (His)

    Dual specificity protein phosphatase 3; DUSP3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR

    Human E. coli
    DUSP3, a dual-specificity phosphatase, preferentially dephosphorylates phosphotyrosines. Its main function involves inactivating ERK1 and ERK2, thereby modulating associated cellular signaling pathways. DUSP3 Protein, Human (His) is the recombinant human-derived DUSP3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of DUSP3 Protein, Human (His) is 184 a.a., with molecular weight of 18-22 kDa.
  • HY-P71632
    LHPP Protein, Human (His-SUMO)

    FLJ44846; FLJ46044; HDHD2B; hLHPP; lhpp

    Human E. coli
    LHPP Protein, a phosphatase, exhibits broad substrate specificity, efficiently hydrolyzing imidodiphosphate, 3-phosphohistidine, and 6-phospholysine. It can also hydrolyze inorganic diphosphate, albeit less efficiently. LHPP Protein, Human (His-SUMO) is the recombinant human-derived LHPP protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of LHPP Protein, Human (His-SUMO) is 270 a.a., with molecular weight of ~45.2 kDa.
  • HY-P74415
    Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His)

    Alkaline phosphatase; AP-TNAP; TNSALP; ALPL

    Mouse HEK293
    Alkaline Phosphatase/ALPL Protein is a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. ALPL is also a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. Mice that lack ALPL show symptoms of osteomalacia, softening of the bones. Moreover, ALPL stimulates mineralization mainly through modulation of the balance between inorganic phosphate (Pi) and inorganic pyrophosphate (PPi) and also has a role in cardiovascular remodelling. Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alkaline Phosphatase/ALPL protein, expressed by HEK293 , with C-His, C-8*His labeled tag. The total length of Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His) is 502 a.a., with molecular weight of ~55 kDa.
  • HY-P75733
    ENPP-2 Protein, Mouse (HEK293, His)

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Autotaxin; LysoPLD; Npps2; Pdnp2

    Mouse HEK293
    ENPP-2 Protein catalyzes the hydrolysis of lysophospholipids, particularly lysophosphatidylcholine, generating the signaling molecule lysophosphatidic acid (LPA). It also acts on sphingosylphosphorylcholine, producing sphingosine-1-phosphate, influencing cell motility. ENPP-2 is involved in angiogenesis, neurite outgrowth, and tumor cell motility, showing a preference for specific lysophospholipid isomers. It plays a role in platelet activation, contributing to LPA production and cleaving sn-1 lysophospholipids. ENPP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-2 protein, expressed by HEK293 , with N-His, N-10*His labeled tag. The total length of ENPP-2 Protein, Mouse (HEK293, His) is 814 a.a., with molecular weight of ~100 kDa.
Cat. No. Product Name Effect Purity