TCPTP Protein, Mouse (sf9, His)

TCPTP, a non-receptor type tyrosine-specific phosphatase, exerts its regulatory influence by dephosphorylating a spectrum of proteins involved in various signaling pathways. This includes receptor protein tyrosine kinases like INSR, EGFR, CSF1R, and PDGFR, as well as non-receptor protein tyrosine kinases such as JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, and STAT6. Operating both in the nucleus and cytoplasm, TCPTP negatively modulates crucial biological processes, spanning hematopoiesis, inflammatory response, cell proliferation, and differentiation, as well as glucose homeostasis. It plays a pivotal role in immune system development, impacting T-cell receptor signaling, macrophage differentiation, and cytokine-mediated pathways. Additionally, TCPTP participates in the negative regulation of growth factor signaling, exemplified by its role in anchorage-dependent control of EGF-stimulated cell growth. Activated by integrin ITGA1/ITGB1, TCPTP dephosphorylates EGFR, PDGFRB, and SRC, exerting regulatory effects on their respective signaling pathways. Notably, TCPTP extends its influence to glucose homeostasis by negatively regulating insulin receptor signaling and controlling gluconeogenesis. Moreover, it may exhibit DNA-binding capabilities.