1. Signaling Pathways
  2. Epigenetics
    JAK/STAT Signaling
    Stem Cell/Wnt
  3. JAK
  4. JAK1 Inhibitors

JAK1 Inhibitors

JAK1

JAK2

JAK3

Tyk2

JAK

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Sorry. There is currently no product that acts on isoform JAK1 together.

Please try each isoform separately.

JAK1 Specific Inhibitors
Product Name JAK1 JAK2 JAK3 Tyk2 JAK1 Selectivity Purity
Abrocitinib
JAK1, IC50: 29 nM
JAK2, IC50: 803 nM
 
Tyk2, IC50: 1253 nM
Selective Inhibitor 99.79%
Itacitinib
JAK1
      Selective Inhibitor 99.87%
Itacitinib adipate
JAK1
      Selective Inhibitor 99.37%
JAK1-IN-3
JAK1, IC50: 73 nM
      Selective Inhibitor 99.32%
JAK1-IN-4
JAK1, IC50: 85 nM
JAK2, IC50: 12.8 μM
    Selective Inhibitor
Ruxolitinib
JAK1, IC50: 3.3 nM
JAK2, IC50: 2.8 nM
JAK3, IC50: 428 nM
Tyk2, IC50: 19 nM
Pan Inhibitor 99.99%
Baricitinib
JAK1, IC50: 5.9 nM
JAK2, IC50: 5.7 nM
JAK3, IC50: 560 nM
Tyk2, IC50: 53 nM
Pan Inhibitor 99.93%
Tofacitinib
JAK1, IC50: 112 nM
JAK2, IC50: 20 nM
JAK3, IC50: 1 nM
  Pan Inhibitor 99.96%
Momelotinib
JAK1, IC50: 11 nM
JAK2, IC50: 18 nM
JAK3, IC50: 155 nM
  Pan Inhibitor 98.11%
AZD-1480
JAK1, IC50: 1.3 nM
JAK2, IC50: 0.4 nM
    Pan Inhibitor 99.37%
Filgotinib
JAK1, IC50: 10 nM
JAK2, IC50: 28 nM
JAK3, IC50: 810 nM
Tyk2, IC50: 116 nM
Pan Inhibitor 99.64%
Peficitinib
JAK1, IC50: 3.9 nM
JAK2, IC50: 5 nM
JAK3, IC50: 0.7 nM
Tyk2, IC50: 4.8 nM
Pan Inhibitor 99.43%
Delgocitinib
JAK1, IC50: 2.8 nM
JAK2, IC50: 2.6 nM
JAK3, IC50: 13 nM
Tyk2, IC50: 58 nM
Pan Inhibitor 99.14%
BMS-911543
JAK1, IC50: 75 nM
JAK2, IC50: 1.1 nM
JAK3, IC50: 360 nM
Tyk2, IC50: 66 nM
Pan Inhibitor 98.12%
Decernotinib
JAK1, Ki: 11 nM
JAK2, Ki: 13 nM
JAK3, Ki: 2.5 nM
Tyk2, Ki: 11 nM
Pan Inhibitor 98.91%
Oclacitinib maleate
JAK1, IC50: 10 nM
JAK2, IC50: 18 nM
JAK3, IC50: 99 nM
Tyk2, IC50: 84 nM
Pan Inhibitor 99.53%
Baricitinib phosphate
JAK1, IC50: 5.9 nM
JAK2, IC50: 5.7 nM
JAK3, IC50: 560 nM
Tyk2, IC50: 53 nM
Pan Inhibitor 99.49%
Ilginatinib
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Pan Inhibitor 95.88%
SAR-20347
JAK1, IC50: 23 nM
JAK2, IC50: 26 nM
JAK3, IC50: 41 nM
Tyk2, IC50: 0.6 nM
Pan Inhibitor 97.00%
NVP-BSK805 dihydrochloride
JAK1 JH1, IC50: 31.63 nM
JAK2 JH1, IC50: 0.48 nM
FL JAK2 V617F, IC50: 0.56 nM
FL JAK2 wt, IC50: 0.58 nM
JAK3 JH1, IC50: 18.68 nM
TYK2 JH1, IC50: 10.76 nM
Pan Inhibitor 99.36%
ZM39923 hydrochloride
JAK1, pIC50: 4.4
 
JAK3, pIC50: 7.1
  Pan Inhibitor >98.0%
Ilginatinib maleate
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Pan Inhibitor 97.04%
JAK3-IN-1
JAK1, IC50: 896 nM
JAK2, IC50: 1050 nM
JAK3, IC50: 4.8 nM
  Pan Inhibitor 99.98%
Ilginatinib hydrochloride
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Pan Inhibitor 98.02%
Momelotinib sulfate
JAK1, IC50: 11 nM
JAK2, IC50: 18 nM
JAK3, IC50: 155 nM
  Pan Inhibitor >96.0%
NVP-BSK805
JAK1 JH1, IC50: 31.63 nM
JAK2 JH1, IC50: 0.48 nM
FL JAK2 V617F, IC50: 0.56 nM
FL JAK2 wt, IC50: 0.58 nM
JAK3 JH1, IC50: 18.68 nM
TYK2 JH1, IC50: 10.76 nM
Pan Inhibitor
PF-06263276
JAK1, IC50: 2.2 nM
JAK2, IC50: 23.1 nM
JAK3, IC50: 59.9 nM
Tyk2, IC50: 29.7 nM
Pan Inhibitor
JAK-IN-3
JAK1, IC50: 5 nM
JAK2, IC50: 70 nM
JAK3, IC50: 3 nM
Tyk2, IC50: 34 nM
Pan Inhibitor
JAK/HDAC-IN-1
JAK1, IC50: 4.8 nM
JAK2, IC50: 4 nM
JAK3, IC50: 7.4 nM
Tyk2, IC50: 49 nM
Pan Inhibitor
Momelotinib Mesylate
JAK1, IC50: 11 nM
JAK2, IC50: 18 nM
JAK3, IC50: 155 nM
  Pan Inhibitor
Ruxolitinib sulfate
JAK1, IC50: 3.3 nM
JAK2, IC50: 2.8 nM
JAK3, IC50: 428 nM
Tyk2, IC50: 19 nM
Pan Inhibitor
ZM39923
JAK1, pIC50: 4.4
 
JAK3, pIC50: 7.1
  Pan Inhibitor