937272-79-2
937272-79-2
Chemical Structure
Pacritinib
Synonym(s): SB1518
- CAS No.: 937272-79-2
- Formula:C28H32N4O3
- Molecular Weight:472.58
IUPAC Name: (22Z,23E,8E)-44-(2-(pyrrolidin-1-yl)ethoxy)-21,22-dihydro-6,11-dioxa-3-aza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene
InChIKey: HWXVIOGONBBTBY-ONEGZZNKSA-N
SMILES: C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1
Biological Activity: Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pacritinib | 99.88% | Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). | ||||||||||||||||||||
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Pacritinib (Standard) | ≥98% | Pacritinib (Standard) is the analytical standard of Pacritinib. This product is intended for research and analytical applications. Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). | ||||||||||||||||||||
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Pacritinib-d4 | 98.42% | Pacritinib-d8 (SB1518-d8) is the deuterium labeled Pacritinib (HY-16379). Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). | ||||||||||||||||||||
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