Pacritinib (Standard)
Pacritinib (Standard) (SB1518 (Standard)) is the analytical standard of Pacritinib (HY-16379). This product is intended for research and analytical applications. Pacritinib (SB1518) is an orally active, selective JAK2/FLT3 inhibitor with IC50 values of 23 nM and 22 nM, respectively. Pacritinib inhibits downstream STAT5, ERK1/2, and AKT signaling, and induces Apoptosis and G1 phase arrest. Pacritinib normalizes tumor-induced cytokines/chemokines, and reduces metastasis, tumor growth, shrinkage, migration, liver injury, inflammation, and steatosis. Pacritinib can be used in research on acute myeloid leukemia, myeloproliferative neoplasms, leukemia/lymphoma, GVHD, and alcoholic/non-alcoholic liver fibrosis.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 937272-79-2
- Formula: C₂₈H₃₂N₄O₃
- Molecular Weight:472.58
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
-
HY-16379
PacritinibJAK2/FLT3 Inhibitor -
HY-12000
AG490EGFR Inhibitor -
HY-10409
FedratinibJAK2 Inhibitor -
HY-50856
RuxolitinibJAK1/2 Inhibitor -
HY-15315
BaricitinibJAK1/2 Inhibitor -
HY-12432
GilteritinibFLT3/AXL Inhibitor -
HY-15002
AST 487c-Kit Inhibitor -
HY-40354A
Tofacitinib citrateJAK1/JAK3 Inhibitor -
HY-18300
FilgotinibJAK1 Inhibitor -
HY-50858
Ruxolitinib phosphateJAK1/2 Inhibitor -
HY-15270
BMS-911543JAK2 Inhibitor -
HY-12333
DenfivontinibFLT3 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 937272-79-2
-
Molecular Weight 472.58
-
Formula C₂₈H₃₂N₄O₃
-
SMILES
C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1
-
Synonyms
SB1518 (Standard)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hart S, et al. Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia. Blood cancer journal. 2011 Nov;1(11):e44. [Content Brief]
[2]. Novotny-Diermayr V, et al. The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. Blood cancer journal. 2012 May;2(5):e69. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pacritinib (Standard) Related Classifications
HY-16379R Related Classifications
Powered by Bioz