Lactic Acid Metabolite Compound Library

Cat. No.: HY-L250

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In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies.

The MCE lactic acid metabolite compound library contains 62 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.

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Biological Activity
Product Details
Composition

Description & Advantages

• A unique collection of 62 lactic acid metabolites

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

• Structurally diverse, bioactive, and cell permeable.

• More detailed compound information with structure, IC50, and other chemical & biological data.

• High purity and quality validated by NMR and LC/MS.

• All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 62 lactic acid metabolites supplied as pre-dissolved Solutions or Solid.
Solution: 62 compounds supplied in 10 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Documentation

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Library Handling Instructions (351 KB)

Composition

Endogenous Metabolite (53)

Environmental Pollutants (11)

Bacterial (8)

Reactive Oxygen Species (ROS) (6)

Antibiotic (3)

Apoptosis (3)

Tyrosinase (3)

COX (2)

Drug Intermediate (2)

GABA Receptor (2)

NF-κB (2)

p38 MAPK (2)

Akt (1)

Amino Acid Decarboxylase (1)

Autophagy (1)

Dopamine Receptor (1)

Drug Derivative (1)

Drug Isomer (1)

Fungal (1)

Glutathione Peroxidase (1)

iGluR (1)

mGluR (1)

MOFs (1)

mTOR (1)

nAChR (1)

Oxidative Phosphorylation (1)

Parasite (1)

PI3K (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

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Plate Map
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Form (Solid or Solution)
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