2. Recombinant Proteins
  3. Kinases

Kinases

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Kinases are enzymes that catalyze the transfer of a phosphate group from ATP to substrate molecules, regulating their activity through phosphorylation. The human genome encodes about 538 kinases, which play key roles in cell signaling and regulate processes such as cell proliferation, differentiation, and metabolism. Dysregulation of kinases is associated with many diseases, making them important therapeutic targets.

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Cat. No. Product Name / Synonyms Species Source Image
  • HY-P73422
    Src Protein, Human (Active, sf9, His-GST)

    Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; SRC1

    		Human Sf9 insect cells
    Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P72938
    HGFR Protein, Human (Active, sf9, His-GST)

    Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET

    		Human Sf9 insect cells
    The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (sf9, His-GST) is the recombinant human-derived HGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P72987
    EGFR Protein, Human (Active, sf9, His-GST)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    		Human Sf9 insect cells
    EGFR is a transmembrane glycoprotein. EGFR binds to ligands, triggering receptor dimerization, inducing intracellular TK domain autophosphorylation, activating downstream Ras/MAPK, PI3K/Akt and other signaling pathways, and regulating cell proliferation, survival, migration and angiogenesis. EGFR Protein, Human (sf9, His-GST) is a recombinant EGFR protein expressed by Sf9 insect cells with N-His, N-GST tags.
  • HY-P72991
    EphA2 Protein, Human (Active, sf9, His-GST)

    Ephrin type-A receptor 2; Epithelial cell kinase; EPHA2; ECK

    		Human Sf9 insect cells
    EphA2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with various ephrin A ligands, affecting cell migration, adhesion, proliferation and differentiation. It regulates cell adhesion and differentiation by interacting with DSG1 and inhibiting the ERK1/ERK2 signaling pathway. EphA2 Protein, Human (sf9, His-GST) is the recombinant human-derived EphA2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P73255
    IRAK4 Protein, Human (Active, sf9, His)

    Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64

    		Human Sf9 insect cells
    The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (Active, sf9, His) is the recombinant human-derived IRAK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.
    (1)
  • HY-P73283
    LYNa Protein, Human (Active, sf9, GST)

    Hck-2; JTK8; Tyrosine-protein kinase Lyn

    		Human Sf9 insect cells
    Lyn protein is a non-receptor tyrosine protein kinase that centrally mediates signals from diverse cell surface receptors, regulating immune responses, hematopoiesis, and integrin signaling. It acts as a negative or positive regulator depending on the context, affecting B cell responses, differentiation and inflammatory responses. LYNa Protein, Human (Active, sf9, GST) is the recombinant human-derived LYNa protein, expressed by Sf9 insect cells , with N-GST labeled tag.
    (1)
  • HY-P73390
    ROR1 Protein, Human (sf9, His)

    Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1

    		Human Sf9 insect cells
    ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
  • HY-P73678
    RET Protein, Human (Active, sf9, His-GST)

    Proto-oncogene tyrosine-protein kinase receptor Ret; RET; CDHF12; CDHR16

    		Human Sf9 insect cells
    RET protein is a receptor tyrosine protein kinase that plays a key role in cell proliferation, neuronal navigation, and differentiation upon binding to glial cell-derived neurotrophic factor family ligands. It regulates the delicate balance between cell death and survival, influences positional information, and is critical for intestinal organogenesis, enteric nervous system development, renal organogenesis, and Peyer's patch formation. RET Protein, Human (sf9, His-GST) is the recombinant human-derived RET protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P74522
    TGFBR1/ALK-5 Protein, Human (Active, sf9, His-GST)

    TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5

    		Human Sf9 insect cells
    TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P74615
    Protein Kinase D2/PRKD2 Protein, Human (Active, sf9, His-GST)

    Serine/threonine-protein kinase D2; PRKD2; PKD2; HSPC187

    		Human Sf9 insect cells
    Protein kinase D2 (PRKD2) is a serine/threonine protein kinase that mediates various cellular processes downstream of PKC. It affects cell proliferation through MAPK1/3 (ERK1/2) signaling, activates NF-kappa-B under oxidative stress, inhibits HDAC7 transcriptional repression, and regulates T cell antigen receptor (TCR) signaling, cytokine production, Golgi trafficking, angiogenesis, particle release, and cell adhesion. Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) is the recombinant human-derived protein Kinase D2/PRKD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P76550
    PLK1 Protein, Human (Active, sf9, His)

    Serine/threonine-protein kinase PLK1; PLK-1; STPK13

    		Human Sf9 insect cells
    PLK1 is a serine/threonine protein kinase that centrally coordinates key functions during the M phase of the cell cycle. It regulates centrosome maturation, spindle assembly, cohesin removal, inactivates APC/C inhibitors, and controls mitotic exit and cytokinesis. PLK1 Protein, Human (sf9, His) is the recombinant human-derived PLK1 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.
    (1)
  • HY-P76263
    CSNK2A1 Protein, Human (Active, sf9, GST)

    Casein kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1

    		Human Sf9 insect cells
    CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CSNK2A1 Protein, Human (sf9, GST) is the recombinant human-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
  • HY-P73244
    Insulin R/CD220 Protein, Human (Active, sf9, His-GST)

    CD 220; HHF5; INSR; Insulin R; Insulin receptor; IR

    		Human Sf9 insect cells
    The insulin R/CD220 protein is a receptor tyrosine kinase that coordinates insulin action by phosphorylating substrates such as IRS and SHC upon insulin binding. Phosphorylated IRS activates PI3K-AKT/PKB to exert metabolic effects, and activates Ras-MAPK to promote growth and differentiation. Insulin R/CD220 Protein, Human (sf9, His-GST) is the recombinant human-derived Insulin R/CD220 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P73256
    IRE1 Protein, Human (Active, sf9, His-GST)

    Serine/threonine-protein kinase/endoribonuclease IRE1; IRE1a; ERN1; IRE1

    		Human Sf9 insect cells
    IRE1 is a key serine/threonine protein kinase and endoribonuclease essential for sensing the unfolded protein response (UPR) in the endoplasmic reticulum. In cellular homeostasis, it remains monomeric by binding to HSPA5/BiP. IRE1 Protein, Human (sf9, His-GST) is the recombinant human-derived IRE1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P73269
    Lck Protein, Human (Active, sf9, GST)

    Tyrosine-protein kinase Lck; LSK; LCK; Hck-3

    		Human Sf9 insect cells
    The Lck protein is a non-receptor tyrosine protein kinase that is essential for T cell development and function. Lck is constitutively associated with CD4 and CD8 receptors and is recruited to the TCR/CD3 complex following TCR interaction with MHC. Lck Protein, Human (sf9, GST) is the recombinant human-derived Lck protein, expressed by Sf9 insect cells , with N-GST labeled tag.
    (1)
  • HY-P73282
    LOK Protein, Human (Active, His)

    Serine/threonine-protein kinase 10; STK10; LOK

    		Human E. coli
    LOK is an important serine/threonine protein kinase that significantly regulates lymphocyte migration by phosphorylating MSN and potentially PLK1. It acts as a negative regulator of MAP3K1/MEKK1. LOK Protein, Human (His) is the recombinant human-derived LOK protein, expressed by E. coli , with N-His labeled tag.
    (1)
  • HY-P73423
    Src Protein, Mouse (Active, sf9, His-GST)

    Proto-oncogene tyrosine-protein kinase Src; Src; p60-Src; SRC1

    		Mouse Sf9 insect cells
    Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P73858
    IRE1 Protein, Human (sf9)

    Serine/threonine-protein kinase/endoribonuclease IRE1; IRE1a; ERN1; IRE1

    		Human Sf9 insect cells
    IRE1 is a key serine/threonine protein kinase and endoribonuclease essential for sensing the unfolded protein response (UPR) in the endoplasmic reticulum. In cellular homeostasis, it remains monomeric by binding to HSPA5/BiP. IRE1 Protein, Human (sf9) is the recombinant human-derived IRE1 protein, expressed by Sf9 insect cells , with tag free.
  • HY-P74114
    GSK-3 beta Protein, Human (Active, sf9, His)

    Glycogen synthase kinase-3 beta; GSK-3 beta; Gsk3b

    		Human Sf9 insect cells
    GSK-3β is a serine-threonine kinase and negative regulator of glucose homeostasis. GSK-3β has been implicated in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. GSK-3β is widely expressed in multiple tissues, with particularly high levels in the brain and thyroid gland. GSK-3 beta Protein, Human (sf9, His) is the recombinant human-derived GSK-3 beta protein, expressed by Sf9 insect cells , with N-His labeled tag.
    (1)
  • HY-P74741
    MST4/STK26 Protein, Human (Active, sf9, GST)

    Serine/threonine-protein kinase 26; MST-4; STK26; MASK

    		Human Sf9 insect cells
    MST4/STK26 is a kinase that mediates cell growth, regulates apoptosis, and, together with STK24, is involved in negatively affecting Golgi reorientation during RHO-triggered polarized cell migration. MST4/STK26 enhances autophagic flux by phosphorylating ATG4B at 'Ser-383'. MST4/STK26 Protein, Human (sf9, GST) is the recombinant human-derived MST4/STK26 protein, expressed by Sf9 insect cells , with GST labeled tag.
Cat. No. Product Name Effect Purity