1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HIV Protease

HIV Protease

HIV Protease is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious. Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. Mutations enable HIV to avoid treatments that involve only one drug, so there is growing use of multiple-drug therapies in which both a protease inhibitor AND a reverse transcript inhibitor are combined.

HIV Protease Related Products (20):

Cat. No. Product Name Effect Purity
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS.
  • HY-P0018A
    Pepstatin Trifluoroacetate Inhibitor 99.11%
    Pepstatin Trifluoroacetate is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease.
  • HY-17007
    Saquinavir Inhibitor 99.91%
    Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.
  • HY-15148
    Tipranavir Inhibitor 99.13%
    Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM.
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir sulfate (BMS-232632 sulfate) is a highly selective HIV-1 protease inhibitor for the treatment of HIV infection, and is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate (BMS-232632 sulfate) is a substrate and inhibitor of CYP3A4 and an inhibitor and inducer of P-glycoprotein.
  • HY-P0018
    Pepstatin Inhibitor >98.0%
    Pepstatin is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease.
  • HY-15287A
    Nelfinavir Mesylate Inhibitor 99.02%
    Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) and antiviral agent for the treatment of HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent.
  • HY-14588
    Lopinavir Inhibitor 99.97%
    Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.
  • HY-B0689A
    Indinavir sulfate Inhibitor 99.50%
    Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
  • HY-17041
    Darunavir Ethanolate Inhibitor 99.73%
    Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease.
  • HY-17430
    Amprenavir Inhibitor 99.61%
    Amprenavir (VX-478) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.
  • HY-17040
    Darunavir Inhibitor 99.39%
    Darunavir(TMC114) is an HIV protease inhibitor.
  • HY-15287
    Nelfinavir Inhibitor 98.16%
    Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) and antiviral agent for the treatment of HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.
  • HY-17003
    Saquinavir Mesylate Inhibitor 99.79%
    Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.
  • HY-P0018B
    Pepstatin Ammonium Inhibitor 99.35%
    Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease.
  • HY-19400
    DPC-681 Inhibitor 99.72%
    DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.
  • HY-B0689
    Indinavir Inhibitor
    Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
  • HY-17367
    Atazanavir Inhibitor
    Atazanavir (BMS-232632) is a highly selective HIV-1 protease inhibitor for the treatment of HIV infection, and is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4 and an inhibitor and inducer of P-glycoprotein.
  • HY-19236
    PNU-103017 Inhibitor
    PNU-103017 is an HIV protease inhibitor.
  • HY-U00261
    L-689502 Inhibitor
    L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.
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