1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
    SARS-CoV
  3. Indinavir sulfate

Indinavir sulfate (Synonyms: MK-639 sulfate; L735524 sulfate)

Cat. No.: HY-B0689A Purity: 99.82%
Handling Instructions

Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.71 μM.

For research use only. We do not sell to patients.

Indinavir sulfate Chemical Structure

Indinavir sulfate Chemical Structure

CAS No. : 157810-81-6

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Indinavir sulfate:

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Description

Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.71 μM[3].

In Vitro

Indinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.MK-639 appears to have significant dose-related antiviral activity and is well tolerated [1]. Inhibition constants (K(i)) of the antiviral drug indinavir for the reaction catalyzed by the mutant enzymes were about threefold and 50-fold higher for PR(L24I) and PR(I50V), respectively, relative to PR and PR(G73S). The dimer dissociation constant (K(d)) was estimated to be approximately 20 nM for both PR(L24I) and PR(I50V), and below 5 nM for PR(G73S) and PR. Crystal structures of the mutants PR(L24I), PR(I50V) and PR(G73S) were determined in complexes with indinavir, or the p2/NC substrate analog at resolutions of 1.10-1.50 Angstrom [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

711.87

Formula

C₃₆H₄₉N₅O₈S

CAS No.
SMILES

O=C([[email protected]@H](C[[email protected]](O)CN(CCN(CC1=CN=CC=C1)C2)[[email protected]@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[[email protected]]4C(C=CC=C5)=C5C[[email protected]]4O.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (140.48 mM)

H2O : 50 mg/mL (70.24 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4048 mL 7.0238 mL 14.0475 mL
5 mM 0.2810 mL 1.4048 mL 2.8095 mL
10 mM 0.1405 mL 0.7024 mL 1.4048 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.82%

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Keywords:

IndinavirMK-639L735524MK639MK 639L 735524L-735524HIVHIV ProteaseSARS-CoVHuman immunodeficiency virusSARS coronavirusInhibitorinhibitorinhibit

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Indinavir sulfate
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HY-B0689A
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