1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease

Indinavir sulfate (Synonyms: MK-639 sulfate; L735524 sulfate)

Cat. No.: HY-B0689A Purity: 99.50%
Handling Instructions

Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

For research use only. We do not sell to patients.

Indinavir sulfate Chemical Structure

Indinavir sulfate Chemical Structure

CAS No. : 157810-81-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Indinavir sulfate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. Target: HIV Protease Indinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.MK-639 appears to have significant dose-related antiviral activity and is well tolerated [1]. Inhibition constants (K(i)) of the antiviral drug indinavir for the reaction catalyzed by the mutant enzymes were about threefold and 50-fold higher for PR(L24I) and PR(I50V), respectively, relative to PR and PR(G73S). The dimer dissociation constant (K(d)) was estimated to be approximately 20 nM for both PR(L24I) and PR(I50V), and below 5 nM for PR(G73S) and PR. Crystal structures of the mutants PR(L24I), PR(I50V) and PR(G73S) were determined in complexes with indinavir, or the p2/NC substrate analog at resolutions of 1.10-1.50 Angstrom [2].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4048 mL 7.0238 mL 14.0475 mL
5 mM 0.2810 mL 1.4048 mL 2.8095 mL
10 mM 0.1405 mL 0.7024 mL 1.4048 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

711.87

Formula

C₃₆H₄₉N₅O₈S

CAS No.

157810-81-6

SMILES

O=C([[email protected]@H](C[[email protected]](O)CN(CCN(CC1=CN=CC=C1)C2)[[email protected]@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[[email protected]]4C(C=CC=C5)=C5C[[email protected]]4O.O=S(O)(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Indinavir sulfate
Cat. No.:
HY-B0689A
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Indinavir sulfate

Cat. No.: HY-B0689A