1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
    SARS-CoV
  3. Lopinavir

Lopinavir  (Synonyms: ABT-378)

Cat. No.: HY-14588 Purity: 99.93%
COA Handling Instructions

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.

For research use only. We do not sell to patients.

Lopinavir Chemical Structure

Lopinavir Chemical Structure

CAS No. : 192725-17-0

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
Solid
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
250 mg USD 192 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Lopinavir:

Top Publications Citing Use of Products

    Lopinavir purchased from MCE. Usage Cited in: Antiviral Res. 2022 Nov 10;105463.  [Abstract]

    Lopinavir (LPV) (1, 5, 10, 20, 50 µM; 12, 24, 36, 48 h) inhibits the growth of U87 cells.

    Lopinavir purchased from MCE. Usage Cited in: Antiviral Res. 2022 Nov 10;105463.  [Abstract]

    Lopinavir (LPV) (0, 1, 5, 10, 20 μM; 24 h) inhibits autophagy in U87 cells in a dose-dependent manner.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

    In Vitro

    HIV-1 protease is an essential enzyme for production of mature, infective virus[1].
    Lopinavir potently inhibits wild-type and mutant HIV protease (Ki= 1.3 to 3.6 pM), blocks the replication of laboratory and clinical strains of HIV type 1 (EC50=0.006 to 0.017 μM), and maintains high potency against mutant HIV selected by Ritonavir in vivo (EC50=≤0.06 μM)[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    628.80

    Formula

    C37H48N4O5

    CAS No.
    SMILES

    CC1=C(OCC(N[[email protected]@H](CC2=CC=CC=C2)[[email protected]@H](O)C[[email protected]](CC3=CC=CC=C3)NC([[email protected]](C(C)C)N4C(NCCC4)=O)=O)=O)C(C)=CC=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (397.58 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5903 mL 7.9517 mL 15.9033 mL
    5 mM 0.3181 mL 1.5903 mL 3.1807 mL
    10 mM 0.1590 mL 0.7952 mL 1.5903 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 25 mg/mL (39.76 mM); Clear solution

    • 2.

      Add each solvent one by one:  corn oil

      Solubility: 20 mg/mL (31.81 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (3.31 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.93%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Lopinavir
    Cat. No.:
    HY-14588
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