1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
  3. Lopinavir

Lopinavir (Synonyms: ABT-378)

Cat. No.: HY-14588 Purity: 99.97%
Handling Instructions

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.

For research use only. We do not sell to patients.

Lopinavir Chemical Structure

Lopinavir Chemical Structure

CAS No. : 192725-17-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
250 mg USD 192 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM. Target: HIV protease Lopinavir is a potent inhibitor of Rh123 efflux in Caco-2 monolayers with IC50 of 1.7 mM. Lopinavir exposure (72 hours) in LS 180V cells reduces the content of intracellular Rh123. Lopinavir induces P-glycoprotein immunoreactive protein and messenger RNA levels in LS 180V cells. Lopinavir inhibits subtype C clone C6 with IC50 of 9.4 nM. Lopinavir inhibits CYP3A with IC50 of 7.3 mM in human liver microsomes, while produces negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19 and 2D6. Lopinavir (10 mg/kg, orally) results in Cmax of 0.8 μg/mL and oral bioavailability of 25% in rats.

Clinical Trial
Molecular Weight

628.80

Formula

C₃₇H₄₈N₄O₅

CAS No.

192725-17-0

SMILES

CC1=C(OCC(N[[email protected]@H](CC2=CC=CC=C2)[[email protected]@H](O)C[[email protected]](CC3=CC=CC=C3)NC([[email protected]](C(C)C)N4C(NCCC4)=O)=O)=O)C(C)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (159.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5903 mL 7.9517 mL 15.9033 mL
5 mM 0.3181 mL 1.5903 mL 3.1807 mL
10 mM 0.1590 mL 0.7952 mL 1.5903 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Lopinavir
Cat. No.:
HY-14588
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