1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Protease
  3. Lopinavir

Lopinavir (Synonyms: ABT-378)

Cat. No.: HY-14588 Purity: 99.97%
Handling Instructions

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity.

For research use only. We do not sell to patients.

Lopinavir Chemical Structure

Lopinavir Chemical Structure

CAS No. : 192725-17-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
250 mg USD 192 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 9 publication(s) in Google Scholar

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Description

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2].

In Vitro

HIV-1 protease is an essential enzyme for production of mature, infective virus[1].
Lopinavir potently inhibits wild-type and mutant HIV protease (Ki= 1.3 to 3.6 pM), blocks the replication of laboratory and clinical strains of HIV type 1 (EC50=0.006 to 0.017 μM), and maintains high potency against mutant HIV selected by Ritonavir in vivo (EC50=≤0.06 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

628.80

Formula

C₃₇H₄₈N₄O₅

CAS No.

192725-17-0

SMILES

CC1=C(OCC(N[[email protected]@H](CC2=CC=CC=C2)[[email protected]@H](O)C[[email protected]](CC3=CC=CC=C3)NC([[email protected]](C(C)C)N4C(NCCC4)=O)=O)=O)C(C)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (397.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5903 mL 7.9517 mL 15.9033 mL
5 mM 0.3181 mL 1.5903 mL 3.1807 mL
10 mM 0.1590 mL 0.7952 mL 1.5903 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 25 mg/mL (39.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  corn oil

    Solubility: 20 mg/mL (31.81 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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Keywords:

LopinavirABT-378ABT378ABT 378HIVHIV ProteaseHuman immunodeficiency viruswild-typemutantcoadministrationreplicationinfectionInhibitorinhibitorinhibit

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Product Name:
Lopinavir
Cat. No.:
HY-14588
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