1. Anti-infection
  2. SARS-CoV

SARS-CoV

SARS-CoV (SARS coronavirus) is the virus that causes severe acute respiratory syndrome (SARS). Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection.

SARS-CoV Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-13765
    6-Thioguanine Inhibitor >98.0%
    6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.
  • HY-104077
    Remdesivir Inhibitor
    Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.
  • HY-17542
    PLpro inhibitor Inhibitor
    PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.
Isoform Specific Products

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