1. Immunology/Inflammation
    Autophagy
    Anti-infection
  2. Toll-like Receptor (TLR)
    Autophagy
    SARS-CoV
    HSV
  3. Imiquimod

Imiquimod (Synonyms: R 837)

Cat. No.: HY-B0180 Purity: 99.96%
Handling Instructions

Imiquimod (R 837) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID 19.

For research use only. We do not sell to patients.

Imiquimod Chemical Structure

Imiquimod Chemical Structure

CAS No. : 99011-02-6

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Imiquimod:

Top Publications Citing Use of Products

    Imiquimod purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.

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    Description

    Imiquimod (R 837) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID 19[1][2].

    IC50 & Target[1][3]

    TLR7

     

    HSV-1

     

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    240.30

    Formula

    C₁₄H₁₆N₄

    CAS No.

    99011-02-6

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 2.64 mg/mL (10.99 mM; ultrasonic and adjust pH to 2 with HCl)

    DMSO : 2 mg/mL (8.32 mM; ultrasonic and warming and heat to 70°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1615 mL 20.8073 mL 41.6146 mL
    5 mM 0.8323 mL 4.1615 mL 8.3229 mL
    10 mM 0.4161 mL 2.0807 mL 4.1615 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.96%

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    Keywords:

    ImiquimodR 837R837R-837Toll-like Receptor (TLR)AutophagySARS-CoVHSVSARS coronavirusHerpes simplex virushumanpapillomaviruswartsmolluscumcontagiosumactinickeratosisbasal ,cellcarcinomasquamouscellBowen'sdiseasenongenitalinfectionvulvarintraepithelialneoplasiaInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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