1. Immunology/Inflammation
    Autophagy
  2. Toll-like Receptor (TLR)
    Autophagy

Imiquimod (Synonyms: R 837)

Cat. No.: HY-B0180 Purity: 99.57%
Handling Instructions

Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.

For research use only. We do not sell to patients.
Imiquimod Chemical Structure

Imiquimod Chemical Structure

CAS No. : 99011-02-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
100 mg USD 60 In-stock
200 mg USD 78 In-stock
500 mg USD 137 In-stock
1 g   Get quote  
5 g   Get quote  

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Other Forms of Imiquimod:

    Imiquimod purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    Clinical Trial
    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 4.1615 mL 20.8073 mL 41.6146 mL
    5 mM 0.8323 mL 4.1615 mL 8.3229 mL
    10 mM 0.4161 mL 2.0807 mL 4.1615 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    240.3

    Formula

    C₁₄H₁₆N₄

    CAS No.

    99011-02-6

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 2.38 mg/mL (Need ultrasonic and warming)

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 99.57%

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    Inquiry Information

    Product Name:
    Imiquimod
    Cat. No.:
    HY-B0180
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