2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17
  6. IL-17F

IL-17F

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Interleukin-17F (IL-17F) belongs to the IL-17 cytokine family. IL-17F is expressed in activated CD4 T cells, activated monocytes, basophils and mast cells. IL-17F can be produced by differentiated TH17 cells, lamina propria T cells, memory CD4+ T cells, γδ T cells and NKT cells[1]. IL-17F is an inflammatory cytokine that induces many proinflammatory cytokines and chemokines. IL-17F induces TGF-β and IL-2 in vein endothelial cells, induces ICAM1 and GM-CSF expression in airway bronchial epithelial cells, and also induces CCL2, CCL7, TSLP and MMP13 in lung fibroblast cells. IL-17F upregulates the expression of IL-6 and CXCL1 in fibroblasts and epithelial cells. IL-17F induces antimicrobial peptides including hBD-2, S100A7, S100A8 and S100A9 with IL-22. IL-17F can synergize with IL-23 in human eosinophils to promote the production of IL-1β and IL-6[1]. IL-17F is a homodimeric cytokine. IL-17F shares the most similarities with IL-17A (50% homology) and can be produced as an IL-17AF heterodimer. IL-17A, IL-17F and IL-17A/F use the same receptor complex: IL-17RA and IL-17RC heterodimer. And they trigger qualitatively similar signaling pathways, IL-17F exhibits the lowest biological activity among IL-17 and IL-17A/F heterodimer[1][2]. IL-17F shows about 100–1000 times lower affinity to the IL-17RA subunit than IL-17A, and does not compete with IL-17A binding to IL-17RA[1][3]. IL-17F plays a protective role in colon cancer development[4]. Human and mouse IL-17F share only 55.90% sequence identity.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70540
    IL-17F Protein, Human (HEK293, His)

    Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

    		Human HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Human (HEK293, His) is a recombinant human IL-17F protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R31-Q163).
  • HY-P700107AF
    Animal-Free IL-17F Protein, Human (His)

    CANDF6; IL-17F; ML-1; ML1

    		Human E. coli
    IL-17F protein is a key effector cytokine in innate and adaptive immunity that maintains tissue integrity and protects against microorganisms. It acts through the IL17RA-IL17RC receptor complex, activates the NF-kappa-B and MAPkinase pathways, and induces the transcription of immune-related genes. Animal-Free IL-17F Protein, Human (His) is the recombinant human-derived animal-FreeIL-17F protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17F Protein, Human (His) is 133 a.a., with molecular weight of ~15.84 kDa.
  • HY-P700195AF
    Animal-Free IL-17F Protein, Mouse (His)

    Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

    		Mouse E. coli
    IL-17F Protein, a cytokine belonging to the IL-17 family, is produced using recombinant DNA technology without the use of animal-derived materials. It is involved in inflammatory responses and immune regulation. IL-17F Protein offers a safe and ethical alternative for research and therapeutic applications, addressing concerns related to animal-based production methods. Animal-Free IL-17F Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-17F protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17F Protein, Mouse (His) is 133 a.a., with molecular weight of ~15.82 kDa.
  • HY-P7209
    IL-17F Protein, Human

    rHuIL-17F; Cytokine ML-1

    		Human E. coli
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Human is a recombinant human IL-17F protein and is expressed in E. coli. It consists of 133 amino acids (R31-Q163).
  • HY-P72586
    IL-17F Protein, Human (HEK293)

    Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

    		Human HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Human (HEK293) is a recombinant human IL-17F protein and is expressed in HEK293 cells. It consists of 133 amino acids (R31-Q163).
  • HY-P74829
    IL-17F Protein, Rat (sf9, His)

    Cytokine ML-1; IL17F; Interleukin-17F

    		Rat Sf9 insect cells
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Rat (sf9, His) is a recombinant rat IL-17F protein with His tag at the C-terminus and is expressed in sf9 insect cells. It consists of 153 amino acids (M1-A153).
  • HY-P72589
    IL-17A (136a.a)-17F Heterodimer Protein, Human (HEK293, His)

    IL-17A/F Heterodimer; IL-17A&IL-17F Heterodimer

    		Human HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A (136a.a)-17F Heterodimer Protein, Human (HEK293, His) is a recombinant human IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 269 amino acids (IL-17A (I20-A155) & IL-17F (R31-Q163)).
  • HY-P72584
    IL-17F Protein, Mouse (133a.a, HEK293, His)

    Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

    		Mouse HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Mouse (133a.a, HEK293, His) is a recombinant mouse IL-17F protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R29-A161).
  • HY-P77708
    IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi)

    IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F

    		Mouse HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 266 amino acids (IL-17A (A26-A158) & IL-17F (R29-A161)).
  • HY-P78159
    IL-17F Protein, Human (Biotinylated, HEK293, His-Avi)

    Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1

    		Human HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IL-17F protein with His and Avi tags at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R31-Q163).
  • HY-P78160
    IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi)

    Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1

    		Mouse HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17F protein with His and Avi tags at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R29-A161).
  • HY-P78321
    IL-17F Protein, Mouse (HEK293, His-Avi)

    Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1

    		Mouse HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Mouse (HEK293, His-Avi) is a recombinant mouse IL-17F protein with His and Avi tags at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R29-A161).
  • HY-P74831
    IL-17F Protein, Mouse

    Cytokine ML-1; IL17F; Interleukin-17F

    		Mouse E. coli
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Mouse is a recombinant mouse IL-17F protein and is expressed in E. coli. It consists of 133 amino acids (R21-A153).
  • HY-P77713
    IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)

    IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F

    		Human HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 265 amino acids (IL-17A (G24-A155) & IL-17F (R31-Q163)).
  • HY-P72585
    IL-17F Protein, Cynomolgus (HEK293, His)

    Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

    		Cynomolgus HEK293
    IL-17F is an inflammatory homodimeric cytokine that induces many proinflammatory cytokines and chemokines. IL-17F also induces antimicrobial peptides. IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer. IL-17F Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-17F protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (R31-Q163).
  • HY-P74832
    IL-17A-17F Heterodimer Protein, Rhesus Macaque (HEK293, His)

    CTLA-8; IL-17; Interleukin-17A; IL17A; Interleukin-17F; IL-17F; Cytokine ML-1

    		Rhesus Macaque HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant rhesus macaque IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 288 amino acids (IL-17A (M1-A155) & IL-17F (R31-Q163)).
  • HY-P77707
    IL-17A-17F Heterodimer Protein, Mouse (HEK293, His-Avi)

    IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F

    		Mouse HEK293
    IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A-17F Heterodimer Protein, Mouse (HEK293, His-Avi) is a recombinant mouse IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 266 amino acids (IL-17A (A26-A158) & IL-17F (R29-A161)).
Cat. No. Product Name Effect Purity