CC Chemokines
CC chemokines, a class of soluble proteins with low molecular weight (8-15 kDa) and an N-terminal CC structural domain, were originally identified as mediators of inflammatory processes and regulators of leukocyte transport. All chemokines share the same overall structure: at least three β-folded sheets, an α-helix in the C-terminal domain, and a disulfide bond connecting conserved cysteine residues. Depending on the arrangement of the first two N-terminal cysteine residues in their amino acid sequence, chemokines can be divided into four families: the CXC (or α) family, the CC (or β) family, the CX3C (or δ) family, and the C (or γ) family. Most chemokines exert their biological effects through the activation of G protein-coupled seven transmembrane receptors (GPCR). Chemokines are a class of soluble cytokines that act as chemoattractants to direct the migration of cells (especially immune cells) and are also involved in cell proliferation, differentiation and survival and are associated with a variety of human diseases, including chronic inflammation, immune dysfunction, cancer and metastasis[1][2].
- [1]. Jan Korbecki, et al. CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. Int J Mol Sci. 2020 Oct 15;21(20):7619. [Content Brief]
- [2]. Andreas Bikfalvi, et al. The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment. Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C542-C554. [Content Brief]
- MCP-1/CCL2 (14)
- CCL17 (11)
- RANTES/CCL5 (9)
- MIP-3 alpha/CCL20 (9)
- CCL21 (9)
- Eotaxin-2/CCL24 (8)
- CCL1 (7)
- MIP-1 alpha/CCL3 (7)
- MCP-2 Protein/CCL8 (6)
- CCL22 (6)
- CCL23 (6)
- MIP-1 beta/CCL4 (5)
- MCP-3 Protein/CCL7 (5)
- Eotaxin/CCL11 (5)
- CCL14 (4)
- MIP-3 beta/CCL19 (4)
- CCL27 (4)
- CCL28 (4)
- CCL18 (3)
- CCL6 (2)
- CCL12 (2)
- CCL13 (2)
- CCL15 (2)
- CCL16 (2)
- CCL25 (2)
- Eotaxin-3/CCL26 (2)
- MIP-1 gamma/CCL9/CCL10 (1)
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CC Chemokines Recombinant Proteins (144)
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Inhibitors & Agonists (298)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
