2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL27

CCL27

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CCL27, also known as skin T-cell attracting chemokine (CTACK), is a CC chemokine located on chromosome 9 in the human genome.CCL27 is abundantly expressed in basal keratin-forming cells. Expression is lowest in basal suprabasal keratin-forming cells of normal skin; however, they exhibit stronger CCL27 expression in lesions of human AD, contact dermatitis, and psoriasis. In addition, CCL27 is present in the dermal extracellular matrix (ECM) of the epidermal plexus, fibroblasts and endothelial cells, especially in inflamed skin . By binding to chemokine receptor 10 (CCR10), CCL27 regulates inflammation by promoting the migration of lymphocytes into the skin. CCL27 contributes to tissue-restricted leukocyte trafficking by exhibiting high receptor and tissue specificity, and induces inflammation by promoting lymphocyte migration into the skin.CCL27 induces expression of cultured normal human keratinocytes (NHEK) via the pro-inflammatory factors TNFα and IL-1[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7767
    CCL27 Protein, Human

    rHuCCL27; C-C Motif Chemokine 27; CC Chemokine ILC; Cutaneous T-Cell-Attracting Chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27

    		Human E. coli
    CCL27 Protein, Human is a CC chemokine that binds to the chemokine receptor CCR10, attracts skin-associated memory T lymphocytes, mediates lymphocyte homing to skin sites, and plays a key role in skin inflammation. CCL27 Protein, Human a recombinant human CCL27(F25-G112) protein expressed by E. coli.
  • HY-P7767A
    CCL27 Protein, Human (N-His)

    rHuCCL27; C-C Motif Chemokine 27; CC Chemokine ILC; Cutaneous T-Cell-Attracting Chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27

    		Human E. coli
    CCL27 protein selectively attracts skin-associated memory T-lymphocytes, mediating their homing to cutaneous sites through CCR10 binding. Crucial for skin immunity regulation, CCL27 exists as a monomer, dimer, and tetramer, with heparin promoting its oligomerization. Interaction with TNFAIP6, particularly through its Link domain, implies regulatory roles in skin immune responses and inflammation within the skin microenvironment. CCL27 Protein, Human (N-His) is the recombinant human-derived CCL27 protein, expressed by E. coli , with N-His labeled tag. The total length of CCL27 Protein, Human (N-His) is 88 a.a., with molecular weight of ~14 kDa.
Cat. No. Product Name Effect Purity