CCL27 Protein, Human (N-His)

CCL27 protein selectively attracts skin-associated memory T-lymphocytes, mediating their homing to cutaneous sites through CCR10 binding. Crucial for skin immunity regulation, CCL27 exists as a monomer, dimer, and tetramer, with heparin promoting its oligomerization. Interaction with TNFAIP6, particularly through its Link domain, implies regulatory roles in skin immune responses and inflammation within the skin microenvironment. CCL27 Protein, Human (N-His) is the recombinant human-derived CCL27 protein, expressed by E. coli , with N-His labeled tag. The total length of CCL27 Protein, Human (N-His) is 88 a.a., with molecular weight of ~14 kDa.

CCL27 protein functions as a chemotactic factor specifically attracting skin-associated memory T-lymphocytes and is implicated in mediating the homing of lymphocytes to cutaneous sites. Through its binding to CCR10, CCL27 orchestrates the migration of immune cells in the skin, indicating its pivotal role in the regulation of skin immunity. Existing as a monomer, dimer, and tetramer, the protein's oligomerization is avidly promoted by heparin. Additionally, CCL27 interacts with TNFAIP6, specifically through its Link domain, suggesting potential regulatory roles in the context of immune responses and inflammatory processes within the skin microenvironment.

Human

E. coli

N-His

Q9Y4X3 (F25-G112)

10850  [NCBI]

Approximately 14 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.