CCL27 - C-C motif chemokine ligand 27 Gene

Also Known as ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10850

About CCL27

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,661,890-34,662,657 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues and 1 paralogue. Biased expression in skin (RPKM 77.8), spleen (RPKM 8.8) and 11 other tissues.

Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to Chemokine Receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

CCL27 Products (1)

mRNA Protein Name
NM_006664.4 NP_006655.1 C-C motif chemokine 27 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables CCR3 chemokine receptor binding IPI
IPI: Inferred from physical interaction
12538707 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28381538 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
19109182 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
19109182 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL27 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 89)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 27

  • CC chemokine ILC

CCL27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCL27 Q9Y4X3 CCL5 Homo sapiens P13501
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL27 Proteins

Cat. No. Product Name Accession Purity
HY-P7767 CTACK/CCL27 Protein, Human Q9Y4X3 (F25-G112) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7767A CTACK/CCL27 Protein, Human (His) Q9Y4X3 (F25-G112) ≥ 95%, as determined by reducing SDS-PAGE.

CCL27 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84895 CCL27 Antibody (YA4592) IHC-P, ICC/IF, FC, ELISA Human
HY-P84895A CCL27 Antibody (YA4592)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Molluscum Contagiosum

  • Water Warts

  • Molluscum Verrucosum
Allergic Contact Dermatitis

  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Hypophosphatasia

  • Phosphoethanolaminuria

  • Childhood Hypophosphatasia

  • Deficiency Of Alkaline Phosphatase

  • Hypophospatasia, Childhood

  • Hypophosphatasia Mild

  • Phosphoethanol-Aminuria

  • Rathburn Disease

  • Hpp

  • Rathbun Disease

  • Hypophosphatasia, Childhood

  • Infantile Hypophosphatasia
Chancroid

  • Ulcus Molle, Skin

  • Chancroids

  • Bubo Due To Haemophilus Ducreyi

  • Soft Chancre

  • Ulcus Molle
Psoriasis
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Irritant Dermatitis

  • Irritant Contact Dermatitis

  • Primary Irritant Dermatitis

  • Dermatitis, Irritant

  • Contact Dermatitis, Irritant

  • Irritant Contact Eczema

  • Icd - [Irritant Contact Dermatitis]

  • Irritant Contact Dermatitis, Unspecified Cause

  • Non-Allergic Contact Dermatitis

  • Irritant Contact Eczema Due To Wet Work

  • Irritant Contact Dermatitis Due To Detergents

  • Irritant Contact Eczema Due To Solvents

  • Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

  • Irritant Contact Eczema Due To Cosmetics Or Emollients

  • Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

  • Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

  • Irritant Contact Eczema Due To Foods

  • Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

  • Irritant Contact Eczema Due To Saliva

  • Irritant Contact Eczema Due To Incontinence

  • Incontinence-Associated Dermatitis
Norwegian Scabies

  • Crusted Scabies

  • Seven Year Itch
Sezary'S Disease

  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02097 CCL27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174755 Human CCL27 mRNA / Unkown
HY-RS25136 Ccl27 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CCL27 VGNC VGNC:102906
Canis familiaris CCL27 VGNC VGNC:38889
Rattus norvegicus CCL27 RGD RGD:1304660
Macaca mulatta CCL27 VGNC VGNC:103246
Bos taurus CCL27 VGNC VGNC:26952
Others CCL27 NCBI