1. PI3K/Akt/mTOR
  2. mTOR

mTOR

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. mTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. mTOR integrates the input from upstream pathways, including insulin, growth factors and amino acids. mTOR also senses cellular nutrient, oxygen, and energy levels. The mTOR pathway is dysregulated in human diseases, such as diabetes, obesity, depression, and certain cancers. Rapamycin inhibits mTOR by associating with its intracellular receptor FKBP12. The FKBP12-rapamycin complex binds directly to the FKBP12-Rapamycin Binding (FRB) domain of mTOR, inhibiting its activity.

mTOR Related Products (53):

Cat. No. Product Name Effect Purity
  • HY-10219
    Rapamycin Inhibitor 98.98%
    Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
  • HY-10218
    Everolimus Inhibitor 98.53%
    Everolimus is a targeted, highly specific agent with an IC50 for binding to isolated FKBP-12, or FKBP-12 complexed to mTOR of 5 to 6 nM, and no significant activity against other protein kinases.
  • HY-16046
    AP1903 Modulator 98.25%
    AP1903 is a homodimer binding to FKBP, elicits potent and dose-dependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
  • HY-50673
    BEZ235 Inhibitor 98.83%
    BEZ235 is a dual pan-class I PI3K and mTOR kinase inhibitor with IC50 of 4 nM/5 nM/7 nM/75 nM, and 6 nM for p110α/γ/δ/β and mTOR (p70S6K), respectively.
  • HY-13328
    INK-128 Inhibitor 99.55%
    INK-128 is a potent and selective mTOR inhibitor with IC50 of 1 nM, > 200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes.
  • HY-50910
    Temsirolimus Inhibitor 98.88%
    Temsirolimus (CCI-779) directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM.
  • HY-13698
    Nandrolone decanoate Activator >98.0%
    Nandrolone decanoate is an anabolic steroid used in doping.
  • HY-10681
    PKI-587 Inhibitor 99.11%
    PKI-587(PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM, 5.4 nM and 1.6 nM for PI3Kα, PI3Kγ and mTOR, respectively.
  • HY-13003
    Torin 1 Inhibitor 99.16%
    Torin 1 is a potent inhibitor of mTORC, with IC50 values of 2 nM and 10 nM against mTORC1 and mTORC2, respectively.
  • HY-13992
    AP20187 Modulator 99.54%
    AP20187 is a cell-permeable molecule used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
  • HY-10422
    AZD-8055 Inhibitor 99.23%
    AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase activity, with an IC50 of 0.8 nM.
  • HY-B0795
    MHY1485 Activator 99.40%
    MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.
  • HY-12513
    LY3023414 Inhibitor 99.70%
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
  • HY-10474
    PP 242 Inhibitor
    PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM.
  • HY-15247
    AZD2014 Inhibitor 98.99%
    AZD2014 is an ATP competitive mTOR inhibitor with IC50 of 2.81 nM.
  • HY-15177
    PF-04691502 Inhibitor 98.58%
    PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
  • HY-13002
    Torin 2 Inhibitor 99.89%
    Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM).
  • HY-10297
    GSK2126458 Inhibitor 99.50%
    GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.
  • HY-50908
    Deforolimus Inhibitor
    Deforolimus (AP23573; MK-8669) is a potent and selective mTOR inhibitor; inhibits S6 phosphorylation with an IC50 of 0.2 nM in HT-1080 cells.
  • HY-10115A
    PI-103 Hydrochloride Inhibitor 99.78%
    PI-103 hydrochloride is a potent PI3K/Akt and mTOR inhibitor with IC50 values of 2 nM for recombinant PI3K isoform p110α and 30 nM for mTOR.