MHY1485
Based on 202 publication(s) in Google Scholar
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 326914-06-1
- Formula: C17H21N7O4
- Molecular Weight:387.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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PI3K/Akt/mTOR Compound Library
HY-L015
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Oxygen Sensing Compound Library
HY-L045
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Glycolysis Compound Library
HY-L058
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Cytoskeleton Compound Library
HY-L060
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
HY-L083
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Angiogenesis-Related Compound Library
HY-L088
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Lipid Metabolism Compound Library
HY-L091
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Glucose Metabolism Compound Library
HY-L092
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Antidepressant Compound Library
HY-L108
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Pain-Related Compound Library
HY-L139
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Cell Death Library
HY-L162
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Multi-Target Compound Library
HY-L176
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) MHY1485
More- Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]
- Cell Stem Cell. 2025 Apr 3;32(4):598-612.e5. [Abstract]
- Nat Aging. 2025 Mar;5(3):468-485. [Abstract]
- Nat Commun. 2025 Nov 7;16(1):9841. [Abstract]
- Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]
- Nat Commun. 2023 Sep 2;14(1):5351. [Abstract]
- Bone Res. 2022 Jun 22;10(1):45. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(21):e18975. [Abstract]
- Adv Sci (Weinh). 2026 Mar;13(13):e01810. [Abstract]
- Adv Sci (Weinh). 2025 Aug 25:e11288. [Abstract]
- Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
- J Adv Res. 2025 Aug:74:589-607. [Abstract]
- J Exp Clin Cancer Res. 2024 Jun 26;43(1):177. [Abstract]
- J Nanobiotechnology. 2026 Feb 3;24(1):130. [Abstract]
- J Nanobiotechnology. 2023 Sep 22;21(1):341. [Abstract]
- Cell Discov. 2026 Feb 24;12(1):13. [Abstract]
- Sci Adv. 2025 Apr 11;11(15):eadq5484. [Abstract]
- Int J Oral Sci. 2024 May 8;16(1):35. [Abstract]
- Redox Biol. 2022 Aug 4;55:102426. [Abstract]
- J Infection. 2019 Sep;79(3):262-276. [Abstract]
- J Control Release. 2025 Apr 25:113778. [Abstract]
- J Hazard Mater. 2025 May 29:494:138769. [Abstract]
- J Immunother Cancer. 2025 Jan 6;13(1):e009265. [Abstract]
- Cancer Lett. 2025 Dec 21:639:218232. [Abstract]
- Cancer Lett. 2024 Mar 31:585:216638. [Abstract]
- Cancer Lett. 2020 Jan 28;469:481-489. [Abstract]
- Int J Biol Sci. 2024 Oct 7;20(14):5415-5435. [Abstract]
- Cell Death Dis. 2025 Feb 17;16(1):103. [Abstract]
- Cell Death Dis. 2023 Mar 25;14(3):211. [Abstract]
- Cell Death Dis. 2022 Jun 20;13(6):557. [Abstract]
- Cell Death Dis. 2022 Apr 21;13(4):387. [Abstract]
- Cell Death Dis. 2022 Jan 12;13(1):53. [Abstract]
- Cell Death Dis. 2020 Mar 3;11(3):164. [Abstract]
- Cell Death Dis. 2019 Feb 13;10(2):140. [Abstract]
- Sci China Life Sci. 2024 Feb;67(2):360-378. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2523789123.
- Cell Commun Signal. 2024 Jun 3;22(1):306. [Abstract]
- Cell Commun Signal. 2021 Feb 26;19(1):29. [Abstract]
- Int J Biol Macromol. 2025 Sep 25;330(Pt 1):147928. [Abstract]
- Int J Biol Macromol. 2025 Sep;322(Pt 3):146900. [Abstract]
- Acta Pharmacol Sin. 2025 Jul;46(7):1864-1876. [Abstract]
- EMBO J. 2025 Oct 20. [Abstract]
- Phytomedicine. 2025 Sep 28:148:157346. [Abstract]
- Phytomedicine. 2025 Sep:145:156939. [Abstract]
- Free Radic Biol Med. 2024 Jan:210:25-41. [Abstract]
- Free Radic Biol Med. 2021 Aug 1:171:112-123. [Abstract]
- Apoptosis. 2026 Jan 12;31(1):42. [Abstract]
- Apoptosis. 2025 Jun;30(5-6):1331-1350. [Abstract]
- Br J Pharmacol. 2025 Jun;182(12):2730-2753. [Abstract]
- J Transl Med. 2025 Sep 24;23(1):1011. [Abstract]
- J Transl Med. 2024 Dec 3;22(1):1095. [Abstract]
- Biomed Pharmacother. 2024 Apr:173:116346. [Abstract]
- J Transl Med. 2023 Feb 3;21(1):74. [Abstract]
- Biomed Pharmacother. 2022 Sep:153:113292. [Abstract]
- Biomed Pharmacother. 2020 Aug;128:110366. [Abstract]
- Chin Med J (Engl). 2025 Jul 22. [Abstract]
- Chin Med J (Engl). 2024 Jul 5;137(13):1563-1575. [Abstract]
- Stem Cell Res Ther. 2021 Apr 29;12(1):254. [Abstract]
- Arch Toxicol. 2024 May;98(5):1369-1381. [Abstract]
- Cell Rep. 2023 Sep 19;42(10):113158. [Abstract]
- Clin Transl Med. 2024 Nov;14(11):e70082. [Abstract]
- Neural Regen Res. 2025 Apr 1;20(4):1178-1191. [Abstract]
- Oncogenesis. 2026 Feb 6;15(1):9. [Abstract]
- Oncogenesis. 2021 Nov 12;10(11):74. [Abstract]
- Phytother Res. 2025 Aug 25. [Abstract]
- Phytother Res. 2024 Apr;38(4):2077-2093. [Abstract]
- Phytother Res. 2020 Jun;34(6):1455-1466. [Abstract]
- J Agric Food Chem. 2025 Sep 24;73(38):24076-24091. [Abstract]
- J Agric Food Chem. 2023 Feb 8. [Abstract]
- Cell Biosci. 2022 Aug 21;12(1):135. [Abstract]
- J Agric Food Chem. 2022 Jul 27;70(29):9187-9200. [Abstract]
- J Agric Food Chem. 2020 Nov 11;68(45):12617-12630. [Abstract]
- Food Biosci. 2025 Jul.
- J Invest Dermatol. 2025 Mar 3:S0022-202X(25)00298-2. [Abstract]
- Plant J. 2024 Jul;119(1):332-347. [Abstract]
- Biochem Pharmacol. 2016 Dec 15:122:42-61. [Abstract]
- World J Gastroenterol. 2024 Jul 14;30(26):3229-3246. [Abstract]
- Mol Ther Oncolytics. 2022 Jun 25;26:175-188. [Abstract]
- Stem Cell Reports. 2026 Apr 14;21(4):102853. [Abstract]
- Cancer Immunol Immunother. 2026 Mar 17;75(4):111. [Abstract]
- Life Sci. 2024 Nov 15:357:123109. [Abstract]
- Commun Biol. 2023 Aug 29;6(1):889. [Abstract]
- Life Sci. 2023 Jul 15:325:121765. [Abstract]
- Drug Des Devel Ther. 2022 Sep 11;16:3071-3085. [Abstract]
- Life Sci. 2019 May 1:224:95-108. [Abstract]
- Respir Res. 2024 May 20;25(1):215. [Abstract]
- CNS Neurosci Ther. 2020 Sep;26(9):952-961. [Abstract]
- Respir Res. 2018 Dec 5;19(1):243. [Abstract]
- Int J Mol Sci. 2025 Apr 11;26(8):3603. [Abstract]
- Pharm Biol. 2023 Dec;61(1):306-315. [Abstract]
- Front Pharmacol. 2021 Nov 22;12:739220. [Abstract]
- Front Pharmacol. 2021 Oct 1;12:727808. [Abstract]
- Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]
- mBio. 2026 Feb 26:e0396525. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116106. [Abstract]
- Eur J Pharmacol. 2025 Dec 5:1008:178303. [Abstract]
- Int Immunopharmacol. 2025 Jan 18:148:114086. [Abstract]
- Eur J Pharmacol. 2023 Oct 15:957:176035. [Abstract]
- Int Immunopharmacol. 2022 Dec;113(Pt B):109407. [Abstract]
- Int Immunopharmacol. 2022 Dec;113(Pt A):109378. [Abstract]
- Reprod Biol Endocrinol. 2022 Apr 18;20(1):67. [Abstract]
- Eur J Pharmacol. 2021 Oct 15:909:174411. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2026 Mar 10;1872(5):168197. [Abstract]
- Mediators Inflamm. 2025 Nov 11:2025:3113542. [Abstract]
- Lipids Health Dis. 2025 May 24;24(1):187. [Abstract]
- J Cell Mol Med. 2025 Jan;29(2):e70352. [Abstract]
- Drug Dev Res. 2024 Nov;85(7):e70004. [Abstract]
- J Cell Mol Med. 2024 Apr;28(8):e18257. [Abstract]
- J Ovarian Res. 2022 Sep 10;15(1):103. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166260. [Abstract]
- Mol Nutr Food Res. 2021 Oct;65(19):e2100367. [Abstract]
- J Cell Mol Med. 2021 Aug;25(15):7342-7353. [Abstract]
- Poultry Sci. 2021 Jan;100(1):334-347. [Abstract]
- Poultry Sci. 2020 Nov;99(11):6147-6162. [Abstract]
- FASEB J. 2019 Dec;33(12):14036-14050. [Abstract]
- Nutr Metab. 2025 May 12;22(1):41. [Abstract]
- J Cell Physiol. 2020 Jul;235(7-8):5764-5776. [Abstract]
- Pestic Biochem Physiol. 2019 Feb:154:67-77. [Abstract]
- J Biol Chem. 2023 Aug;299(8):105015. [Abstract]
- Aging (Albany NY). 2021 Dec 4;13(23):25089-25105. [Abstract]
- Oncol Rep. 2020 Jul;44(1):103-114. [Abstract]
- ACS Chem Neurosci. 2019 Oct 16;10(10):4227-4236. [Abstract]
- J Virol. 2025 Apr 25:e0000225. [Abstract]
- Neurochem Res. 2023 May;48(5):1395-1411. [Abstract]
- Neurochem Res. 2018 Nov;43(11):2141-2154. [Abstract]
- Cell Signal. 2025 Jun 27:111969. [Abstract]
- Cell Signal. 2024 Jun:118:111136. [Abstract]
- Mol Cell Biochem. 2021 Jan;476(1):45-55. [Abstract]
- Heliyon. 2024 Apr 16;10(8):e29404. [Abstract]
- J Nat Prod. 2023 Apr 28;86(4):966-978. [Abstract]
- Heliyon. 2022 Oct 12;8(10):e11013. [Abstract]
- Heliyon. 2020 Jun 3;6(6):e04050. [Abstract]
- Viruses. 2025 Dec 17;17(12):1637. [Abstract]
- Mol Med Rep. 2024 Mar;29(3):49. [Abstract]
- Exp Cell Res. 2022 Jun 1;415(1):113120. [Abstract]
- Food Chem Toxicol. 2021 Mar:149:112037. [Abstract]
- Exp Cell Res. 2018 Jun 15;367(2):186-195. [Abstract]
- Exp Cell Res. 2017 Nov 15;360(2):328-336. [Abstract]
- J Periodontal Res. 2023 Dec;58(6):1300-1314. [Abstract]
- Acta Biochim Biophys Sin (Shanghai). 2021 Dec 8;53(12):1662-1669. [Abstract]
- J Diabetes Res. 2020 Mar 26;2020:4326549. [Abstract]
- Front Oncol. 2022 Mar 2;12:773601. [Abstract]
- Int J Med Sci. 2026 Mar 17;23(4):1567-1576. [Abstract]
- Pathol Res Pract. 2026 Mar:279:156364. [Abstract]
- Environ Toxicol. 2024 Feb;39(2):830-839. [Abstract]
- Cytotherapy. 2023 Aug;25(8):858-865. [Abstract]
- Environ Toxicol. 2023 Aug;38(8):1874-1890. [Abstract]
- Int J Med Sci. 2020 May 18;17(9):1246-1256. [Abstract]
- Cell Biol Int. 2022 Dec;46(12):2095-2106. [Abstract]
- Discov Oncol. 2025 Sep 30;16(1):1789. [Abstract]
- Discov Oncol. 2025 May 16;16(1):788. [Abstract]
- J Pharmacol Sci. 2024 Sep;156(1):1-8. [Abstract]
- Carcinogenesis. 2024 Feb 12;45(1-2):45-56. [Abstract]
- Mol Brain. 2022 Jul 18;15(1):61. [Abstract]
- Toxicol Lett. 2022 Aug 15:367:9-18. [Abstract]
- Toxicol Lett. 2021 Jul 1:345:1-11. [Abstract]
- J Orthop Surg Res. 2025 Jul 9;20(1):631. [Abstract]
- J Cell Biochem. 2018 Jul;119(7):6104-6112. [Abstract]
- Anal Cell Pathol. 2026;2026(1):e3662809. [Abstract]
- BMC Mol Cell Biol. 2024 Apr 23;25(1):13. [Abstract]
- J Assist Reprod Genet. 2023 Mar;40(3):491-508. [Abstract]
- Toxicol In Vitro. 2023 Feb:86:105513. [Abstract]
- Virus Res. 2021 Apr 2:295:198277. [Abstract]
- Dig Dis Sci. 2025 Nov 15. [Abstract]
- Cell Biochem Biophys. 2025 Sep 27. [Abstract]
- J Steroid Biochem Mol Biol. 2025 Jul 3:254:106825. [Abstract]
- World J Surg Oncol. 2025 Apr 2;23(1):115. [Abstract]
- Theriogenology. 2023 Dec:212:91-103. [Abstract]
- Odontology. 2026 Jan 23. [Abstract]
- J Chin Med Assoc. 2025 Sep 3. [Abstract]
- Eur J Neurosci. 2025 May;61(9):e70137. [Abstract]
- PeerJ. 2023 Jun 7:11:e15498. [Abstract]
- Am J Reprod Immunol. 2023 Mar;89(3):e13659. [Abstract]
- J Oral Pathol Med. 2025 Aug;54(7):584-596. [Abstract]
- Exp Ther Med. 2024 Apr 15;27(6):252. [Abstract]
- Biochem Biophys Res Commun. 2026 May 21:814:153669. [Abstract]
- Arch Oral Biol. 2022 Sep:141:105491. [Abstract]
- J Stomatol Oral Maxillofac Surg. 2025 Jul 25:102511. [Abstract]
- Neurosci Lett. 2019 Jun 21:704:50-56. [Abstract]
- Biomed Rep. 2025 Apr 14;22(6):99. [Abstract]
- J Interferon Cytokine Res. 2025 Oct;45(10):335-343. [Abstract]
- Eur J Phycol. 2026 Mar 4.
- Biol Pharm Bull. 2024 Feb 22;47(2):486-498. [Abstract]
- Neuroreport. 2021 Aug 11;32(12):975-982. [Abstract]
- Open Life Sci. 2019 Aug 28:14:400-409. [Abstract]
- Nat Prod Commun. 2023 Jul 4.
- J Vis Exp. 2025 Aug 26:(222). [Abstract]
- Pharmacogn Mag. 2025 Jan 13.
- SSRN. 2025 Nov 8.
- Res Sq. 2025 May 29.
- SSRN. 2025 May 7.
- SSRN. 2025 Apr 19.
- biorxiv. 2024 May 27.
- Research Square Preprint. 2023 Jul 24.
- Research Square Print. 2023 Mar 17.
- Research Square Print. December 15th, 2022.
- Ann Transl Med. 2022 Mar;10(6):291. [Abstract]
- Research Square Preprint. 2021 Apr.
- Research Square Preprint. 2021 Jan.
- Authorea. January 28, 2021.
- Research Square Preprint. 2020 Dec.
- Oncotarget. 2017 Feb 21;8(8):12775-12783. [Abstract]
Customer Validation & Images
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Biological Activity
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mTORC1 |
mTORC2 |
Autophagy |
MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells[1]. MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells[2]. MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCC cells
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Concentration:10 μM
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Incubation Time:4 hours
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Result:Upregulated p-mTOR and downregulated LC3 and p62 expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-week-old female ICR mice[3]
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Dosage:10 mg/kg, 2 days
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Administration:Intraperitoneal injection
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Result:Suppressed the autophagy level following FSH treatment.
Chemical Information
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CAS No. 326914-06-1
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Appearance Solid
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Molecular Weight 387.39
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Formula C17H21N7O4
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Color Off-white to yellow
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SMILES
O=[N+](C1=CC=C(NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (202)
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Journal Impact Factor
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Most Recent
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Mol Cancer
Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. [Abstract]2025 Mar 26;24(1):97. PMID: 40140842 -
Cell Stem Cell
Interferon-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins. [Abstract]2025 Apr 3;32(4):598-612.e5. PMID: 40010349 -
Nat Aging
2025 Mar;5(3):468-485. PMID: 39779911 -
Nat Commun
DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy. [Abstract]2025 Nov 7;16(1):9841. PMID: 41203603 -
Nat Commun
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. [Abstract]2025 Feb 25;16(1):1774. PMID: 40000627 -
Nat Commun
Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. [Abstract]2023 Sep 2;14(1):5351. PMID: 37660128 -
Bone Res
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. [Abstract]2022 Jun 22;10(1):45. PMID: 35729106 -
Adv Sci (Weinh)
Targeting PRKCN, an Essential Driver Orchestrating mTOR-IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma. [Abstract]2026 Apr;13(21):e18975. PMID: 41655233 -
Adv Sci (Weinh)
IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals. [Abstract]2026 Mar;13(13):e01810. PMID: 41486830 -
Adv Sci (Weinh)
PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy. [Abstract]2025 Aug 25:e11288. PMID: 40853330 -
Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Sep 4:e2402393. PMID: 39229959 -
J Adv Res
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. [Abstract]2025 Aug:74:589-607. PMID: 39353532 -
J Exp Clin Cancer Res
Neddylation activated TRIM25 desensitizes triple-negative breast cancer to paclitaxel via TFEB-mediated autophagy. [Abstract]2024 Jun 26;43(1):177. PMID: 38926803 -
J Nanobiotechnology
AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPK-MTOR-autophagy pathway in macrophage. [Abstract]2026 Feb 3;24(1):130. PMID: 41634773 -
J Nanobiotechnology
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis. [Abstract]2023 Sep 22;21(1):341. PMID: 37736726 -
Cell Discov
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]2026 Feb 24;12(1):13. PMID: 41730846 -
Sci Adv
2025 Apr 11;11(15):eadq5484. PMID: 40203091 -
Int J Oral Sci
Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK. [Abstract]2024 May 8;16(1):35. PMID: 38719825 -
Redox Biol
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer. [Abstract]2022 Aug 4;55:102426. PMID: 35963119 -
J Infection
Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling. [Abstract]2019 Sep;79(3):262-276. PMID: 31226272 -
J Control Release
Promoting retinal ganglion cell regeneration with targeted liposome-based delivery of MHY1485 for optic nerve repair. [Abstract]2025 Apr 25:113778. PMID: 40288495 -
J Hazard Mater
TSC2/mTORC1 integrates deoxynivalenol signals recognized by membrane receptors IR and EGFR to restrict intestinal stem cell function. [Abstract]2025 May 29:494:138769. PMID: 40466374 -
J Immunother Cancer
GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy. [Abstract]2025 Jan 6;13(1):e009265. PMID: 39762082 -
Cancer Lett
YTHDF2-mediated stabilization of SREBF1 promotes lipid metabolic reprogramming and ferroptosis-associated radioresistance in anaplastic thyroid carcinoma. [Abstract]2025 Dec 21:639:218232. PMID: 41435981 -
Cancer Lett
C/EBPα mediates the maturation and antitumor functions of macrophages in human hepatocellular carcinoma. [Abstract]2024 Mar 31:585:216638. PMID: 38266805 -
Cancer Lett
FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy. [Abstract]2020 Jan 28;469:481-489. PMID: 31738958 -
Int J Biol Sci
Heterophyllin B enhances transcription factor EB-mediated autophagy and alleviates pyroptosis and oxidative stress after spinal cord injury. [Abstract]2024 Oct 7;20(14):5415-5435. PMID: 39494322 -
Cell Death Dis
WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway. [Abstract]2025 Feb 17;16(1):103. PMID: 39962118 -
Cell Death Dis
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma. [Abstract]2023 Mar 25;14(3):211. PMID: 36966152 -
Cell Death Dis
Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer. [Abstract]2022 Jun 20;13(6):557. PMID: 35725558 -
Cell Death Dis
HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis. [Abstract]2022 Apr 21;13(4):387. PMID: 35449152 -
Cell Death Dis
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages. [Abstract]2022 Jan 12;13(1):53. PMID: 35022393 -
Cell Death Dis
2020 Mar 3;11(3):164. PMID: 32127533 -
Cell Death Dis
Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells. [Abstract]2019 Feb 13;10(2):140. PMID: 30760702
MHY1485 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Feb 13;10(2):140. [Abstract]
Sorted naive T cells are cultured with TGF-β, IL-2 with or without 40 μM Baicalin or 10 μM MHY1485 for 3 h, P-mTOR, p-S6K, P-4EBP1, and GAPDH expression are analyzed by western blot.
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Sci China Life Sci
Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure. [Abstract]2024 Feb;67(2):360-378. PMID: 37815699 -
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Cell Commun Signal
Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF. [Abstract]2024 Jun 3;22(1):306. PMID: 38831454 -
Cell Commun Signal
mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy. [Abstract]2021 Feb 26;19(1):29. PMID: 33637094 -
Int J Biol Macromol
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression. [Abstract]2025 Sep 25;330(Pt 1):147928. PMID: 41015372 -
Int J Biol Macromol
Lentinan rewrites extracellular matrix homeostasis by activating mitophagy via mTOR/PINK1/Parkin pathway in cartilage to alleviating osteoarthritis. [Abstract]2025 Sep;322(Pt 3):146900. PMID: 40819752 -
Acta Pharmacol Sin
Costunolide normalizes neuroinflammation and improves neurogenesis deficits in a mouse model of depression through inhibiting microglial Akt/mTOR/NF-κB pathway. [Abstract]2025 Jul;46(7):1864-1876. PMID: 40011631 -
EMBO J
2025 Oct 20. PMID: 41116059 -
Phytomedicine
Therapeutic potential of xanthohumol in senile osteoporosis: mTOR-driven regulation of AKT/mTOR/p70S6K autophagy axis in D-galactose models. [Abstract]2025 Sep 28:148:157346. PMID: 41056860 -
Phytomedicine
2025 Sep:145:156939. PMID: 40669211 -
Free Radic Biol Med
Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation. [Abstract]2024 Jan:210:25-41. PMID: 37956909 -
Free Radic Biol Med
Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NFκB signaling pathway. [Abstract]2021 Aug 1:171:112-123. PMID: 33992678 -
Apoptosis
Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription. [Abstract]2026 Jan 12;31(1):42. PMID: 41524974 -
Apoptosis
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve. [Abstract]2025 Jun;30(5-6):1331-1350. PMID: 40042747 -
Br J Pharmacol
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1-mediated autophagy. [Abstract]2025 Jun;182(12):2730-2753. PMID: 40052261 -
J Transl Med
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma. [Abstract]2025 Sep 24;23(1):1011. PMID: 40993737 -
J Transl Med
Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis. [Abstract]2024 Dec 3;22(1):1095. PMID: 39623468 -
Biomed Pharmacother
Effects of the combination of Epimedii Folium and Ligustri Lucidi Fructus on apoptosis and autophagy in SOP rats and osteoblasts via PI3K/AKT/mTOR pathway. [Abstract]2024 Apr:173:116346. PMID: 38428312 -
J Transl Med
VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway. [Abstract]2023 Feb 3;21(1):74. PMID: 36737819 -
Biomed Pharmacother
2022 Sep:153:113292. PMID: 35717785 -
Biomed Pharmacother
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration. [Abstract]2020 Aug;128:110366. PMID: 32526459 -
Chin Med J (Engl)
2025 Jul 22. PMID: 40693638 -
Chin Med J (Engl)
METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway. [Abstract]2024 Jul 5;137(13):1563-1575. PMID: 37963715 -
Stem Cell Res Ther
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process. [Abstract]2021 Apr 29;12(1):254. PMID: 33926537 -
Arch Toxicol
Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells. [Abstract]2024 May;98(5):1369-1381. PMID: 38485781 -
Cell Rep
2023 Sep 19;42(10):113158. PMID: 37733588 -
Clin Transl Med
Targeting endoplasmic reticulum stress-induced lymphatic dysfunction for mitigating bisphosphonate-related osteonecrosis. [Abstract]2024 Nov;14(11):e70082. PMID: 39521624 -
Neural Regen Res
Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming. [Abstract]2025 Apr 1;20(4):1178-1191. PMID: 38989955 -
Oncogenesis
Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer. [Abstract]2026 Feb 6;15(1):9. PMID: 41651808 -
Oncogenesis
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathway. [Abstract]2021 Nov 12;10(11):74. PMID: 34772914 -
Phytother Res
4'-Hydroxychalcone Induces Ferroptosis in Glioblastoma Through the xCT/GSH/GPX4 Axis Under the Regulation of the AKT/mTORC1/4EBP1 Pathway. [Abstract]2025 Aug 25. PMID: 40855403 -
Phytother Res
Fraxetin pretreatment alleviates cisplatin-induced kidney injury by antagonizing autophagy and apoptosis via mTORC1 activation. [Abstract]2024 Apr;38(4):2077-2093. PMID: 38558449 -
Phytother Res
Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression. [Abstract]2020 Jun;34(6):1455-1466. PMID: 31828866 -
J Agric Food Chem
Chitosan Oligosaccharide Attenuates Neuroinflammation by Regulating Microglial Immunometabolic Reprogramming via the mTOR Signaling Pathway. [Abstract]2025 Sep 24;73(38):24076-24091. PMID: 40937497 -
J Agric Food Chem
Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. [Abstract]2023 Feb 8. PMID: 36752041 -
Cell Biosci
Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer. [Abstract]2022 Aug 21;12(1):135. PMID: 35989326 -
J Agric Food Chem
mTOR-Mediated Autophagy Regulates Fumonisin B1-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro. [Abstract]2022 Jul 27;70(29):9187-9200. PMID: 35830273 -
J Agric Food Chem
Cinnamtannin D1 Protects Pancreatic β-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo. [Abstract]2020 Nov 11;68(45):12617-12630. PMID: 33125846 -
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J Invest Dermatol
The Repurposing of Nitazoxanide for Psoriasis Treatment Exerts Therapeutic Effects through Skin Metabolic Reprogramming. [Abstract]2025 Mar 3:S0022-202X(25)00298-2. PMID: 40043790 -
Plant J
Cucumber (Cucumis sativus L.) translationally controlled tumor protein interacts with CsRab11A and promotes activation of target of rapamycin in response to Podosphaera xanthii. [Abstract]2024 Jul;119(1):332-347. PMID: 38700955 -
Biochem Pharmacol
Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. [Abstract]2016 Dec 15:122:42-61. PMID: 27816546
MHY1485 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2016 Dec 15:122:42-61. [Abstract]
HepG2 cells were incubated with or without MHY1485 for 1 h, the cells were switched to medium D in the presence of vehicle, or AHI.
-
World J Gastroenterol
Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling. [Abstract]2024 Jul 14;30(26):3229-3246. PMID: 39086630 -
Mol Ther Oncolytics
Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition. [Abstract]2022 Jun 25;26:175-188. PMID: 35860007 -
Stem Cell Reports
Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury. [Abstract]2026 Apr 14;21(4):102853. PMID: 41825445 -
Cancer Immunol Immunother
Mitochondrial impairment and mTORC1 signalling exhaustion define NK Cell dysfunction progression in melanoma. [Abstract]2026 Mar 17;75(4):111. PMID: 41843165 -
Life Sci
Sodium selenite inhibits cervical cancer progression via ROS-mediated suppression of glucose metabolic reprogramming. [Abstract]2024 Nov 15:357:123109. PMID: 39384146 -
Commun Biol
2023 Aug 29;6(1):889. PMID: 37644178 -
Life Sci
d-Glucosamine induces circadian phase delay by promoting BMAL1 degradation through AMPK/mTOR pathway. [Abstract]2023 Jul 15:325:121765. PMID: 37169147 -
Drug Des Devel Ther
Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis. [Abstract]2022 Sep 11;16:3071-3085. PMID: 36118165 -
Life Sci
Apelin-36 exerts the cytoprotective effect against MPP+-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway. [Abstract]2019 May 1:224:95-108. PMID: 30905782 -
Respir Res
Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway. [Abstract]2024 May 20;25(1):215. PMID: 38764025 -
CNS Neurosci Ther
VX-765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke-induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway. [Abstract]2020 Sep;26(9):952-961. PMID: 32459063 -
Respir Res
Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling. [Abstract]2018 Dec 5;19(1):243. PMID: 30518355 -
Int J Mol Sci
Methylmercury Chloride Exposure Affects Oocyte Maturation Through AMPK/mTOR-Mediated Mitochondrial Autophagy. [Abstract]2025 Apr 11;26(8):3603. PMID: 40332119 -
Pharm Biol
Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway. [Abstract]2023 Dec;61(1):306-315. PMID: 36694426 -
Front Pharmacol
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis. [Abstract]2021 Nov 22;12:739220. PMID: 34880752 -
Front Pharmacol
Network Pharmacology-Based Strategy for the Investigation of the Anti-Osteoporosis Effects and Underlying Mechanism of Zhuangguguanjie Formulation. [Abstract]2021 Oct 1;12:727808. PMID: 34658868 -
Front Pharmacol
CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling. [Abstract]2020 Nov 11;11:580407. PMID: 33343350 -
mBio
Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice. [Abstract]2026 Feb 26:e0396525. PMID: 41744685 -
Int Immunopharmacol
PIK3CG deficiency promotes metabolic reprogramming in pancreatic Cancer by suppressing GLS2-driven glutamine metabolism. [Abstract]2026 Mar 1:172:116106. PMID: 41539001 -
Eur J Pharmacol
Doxorubicin-mediated retardation of aggresome formation enhances Carfilzomib-induced cell death synergistically by augmenting ER stress and proapoptotic signaling. [Abstract]2025 Dec 5:1008:178303. PMID: 41183585 -
Int Immunopharmacol
Plumbagin improves myocardial fibrosis after myocardial infarction by inhibiting the AKT/mTOR pathway to upregulate autophagy levels. [Abstract]2025 Jan 18:148:114086. PMID: 39827666 -
Eur J Pharmacol
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. [Abstract]2023 Oct 15:957:176035. PMID: 37657741 -
Int Immunopharmacol
Rapamycin regulates osteogenic differentiation through Parkin-mediated mitophagy in rheumatoid arthritis. [Abstract]2022 Dec;113(Pt B):109407. PMID: 36379150 -
Int Immunopharmacol
D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway. [Abstract]2022 Dec;113(Pt A):109378. PMID: 36327873 -
Reprod Biol Endocrinol
Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation. [Abstract]2022 Apr 18;20(1):67. PMID: 35436937 -
Eur J Pharmacol
Integrating network pharmacology and experimental models to investigate the mechanisms of dihydroartemisinin in preventing NSCLC progression via mTOR/HIF-1α signaling. [Abstract]2021 Oct 15:909:174411. PMID: 34390710 -
Biochim Biophys Acta Mol Basis Dis
Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition. [Abstract]2026 Mar 10;1872(5):168197. PMID: 41812529 -
Mediators Inflamm
Neutrophil-Fibroblast Crosstalk Drives Immunofibrosis in Sequelae of Pelvic Inflammatory Disease Through Neutrophil Extracellular Traps. [Abstract]2025 Nov 11:2025:3113542. PMID: 41262541 -
Lipids Health Dis
Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation. [Abstract]2025 May 24;24(1):187. PMID: 40413480 -
J Cell Mol Med
Stromal Cell Derived Factor-1 Promotes Hepatic Insulin Resistance via Inhibiting Hepatocyte Lipophagy. [Abstract]2025 Jan;29(2):e70352. PMID: 39855896 -
Drug Dev Res
Knockdown of ENO1 promotes autophagy dependent-ferroptosis and suppresses glycolysis in breast cancer cells via the regulation of CST1. [Abstract]2024 Nov;85(7):e70004. PMID: 39503165 -
J Cell Mol Med
Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1/TFEB/ABCA1-SCARB1 signal axis. [Abstract]2024 Apr;28(8):e18257. PMID: 38526033 -
J Ovarian Res
UBE2T regulates epithelial-mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer. [Abstract]2022 Sep 10;15(1):103. PMID: 36088429 -
Biochim Biophys Acta Mol Basis Dis
SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. [Abstract]2021 Dec 1;1867(12):166260. PMID: 34461258 -
Mol Nutr Food Res
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner. [Abstract]2021 Oct;65(19):e2100367. PMID: 34331380 -
J Cell Mol Med
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. [Abstract]2021 Aug;25(15):7342-7353. PMID: 34213839 -
Poultry Sci
The relationship between the mTOR signaling pathway and ovarian aging in peak-phase and late-phase laying hens. [Abstract]2021 Jan;100(1):334-347. PMID: 33357698 -
Poultry Sci
Melatonin regulates chicken granulosa cell proliferation and apoptosis by activating the mTOR signaling pathway via its receptors. [Abstract]2020 Nov;99(11):6147-6162. PMID: 33142533 -
FASEB J
G9a promotes cell proliferation and suppresses autophagy in gastric cancer by directly activating mTOR. [Abstract]2019 Dec;33(12):14036-14050. PMID: 31647887 -
Nutr Metab
2025 May 12;22(1):41. PMID: 40355931 -
J Cell Physiol
IFN-γ/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation. [Abstract]2020 Jul;235(7-8):5764-5776. PMID: 31970777 -
Pestic Biochem Physiol
Natural β-carboline alkaloids regulate the PI3K/Akt/mTOR pathway and induce autophagy in insect Sf9 cells. [Abstract]2019 Feb:154:67-77. PMID: 30765058 -
J Biol Chem
The FSH-mTOR-CNP signaling axis initiates follicular antrum formation by regulating tight junction, ion pumps, and aquaporins. [Abstract]2023 Aug;299(8):105015. PMID: 37414146 -
Aging (Albany NY)
The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism. [Abstract]2021 Dec 4;13(23):25089-25105. PMID: 34863080 -
Oncol Rep
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway. [Abstract]2020 Jul;44(1):103-114. PMID: 32627037 -
ACS Chem Neurosci
Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate. [Abstract]2019 Oct 16;10(10):4227-4236. PMID: 31545891 -
J Virol
Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes. [Abstract]2025 Apr 25:e0000225. PMID: 40277356 -
Neurochem Res
Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson's Disease Models. [Abstract]2023 May;48(5):1395-1411. PMID: 36469163 -
Neurochem Res
DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-Induced NGF Expression in Schwann Cells. [Abstract]2018 Nov;43(11):2141-2154. PMID: 30229399
MHY1485 purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2018 Nov;43(11):2141-2154. [Abstract]
MHY1485 (M) increases phospho-mTOR (Ser 2448), phosphoS6K1 (Thr 389) and NGF expression in RSC96 cells.
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Cell Signal
RLIG1 promotes triple-negative breast cancer proliferation by activating mTORC1 signal pathway by interacting with ERK. [Abstract]2025 Jun 27:111969. PMID: 40582436 -
Cell Signal
microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression. [Abstract]2024 Jun:118:111136. PMID: 38471617 -
Mol Cell Biochem
Isoflurane promotes proliferation of squamous cervical cancer cells through mTOR-histone deacetylase 6 pathway. [Abstract]2021 Jan;476(1):45-55. PMID: 32833118 -
Heliyon
Qingfei mixture modulates the immune responses in lung cancer through modulating mTOR signaling and gut microbiota-derived short-chain fatty acids. [Abstract]2024 Apr 16;10(8):e29404. PMID: 38660245 -
J Nat Prod
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma. [Abstract]2023 Apr 28;86(4):966-978. PMID: 37043698 -
Heliyon
3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway. [Abstract]2022 Oct 12;8(10):e11013. PMID: 36276736 -
Heliyon
Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition. [Abstract]2020 Jun 3;6(6):e04050. PMID: 32529067 -
Viruses
Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway. [Abstract]2025 Dec 17;17(12):1637. PMID: 41472306 -
Mol Med Rep
Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice. [Abstract]2024 Mar;29(3):49. PMID: 38275127 -
Exp Cell Res
Metformin alleviates dexamethasone-induced apoptosis by regulating autophagy via AMPK/mTOR/p70S6K in osteoblasts. [Abstract]2022 Jun 1;415(1):113120. PMID: 35341775 -
Food Chem Toxicol
Fumonisin B1 induces nephrotoxicity via autophagy mediated by mTORC1 instead of mTORC2 in human renal tubule epithelial cells. [Abstract]2021 Mar:149:112037. PMID: 33548371 -
Exp Cell Res
Hyperglycemia-induced Bcl-2/Bax-mediated apoptosis of Schwann cells via mTORC1/S6K1 inhibition in diabetic peripheral neuropathy. [Abstract]2018 Jun 15;367(2):186-195. PMID: 29621478
MHY1485 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2018 Jun 15;367(2):186-195. [Abstract]
MHY1485 prevents high glucose-caused reduced phospho-S6K1 (Thr 389) and cell apoptosis in RSC96 cells.
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Exp Cell Res
miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin. [Abstract]2017 Nov 15;360(2):328-336. PMID: 28928082
MHY1485 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2017 Nov 15;360(2):328-336. [Abstract]
HT29 cells are co-treated with 5-FU and MHY1485 (MHY) for 48 h. Proteins are collected and immunoblotted with mTOR, p-p70S6K, and p70S6K, with β-actin as the loading control.
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J Periodontal Res
Proanthocyanidin enhances the endogenous regeneration of alveolar bone by elevating the autophagy of PDLSCs. [Abstract]2023 Dec;58(6):1300-1314. PMID: 37715945 -
Acta Biochim Biophys Sin (Shanghai)
Epicatechin gallate prevents the de novo synthesis of fatty acid and the migration of prostate cancer cells. [Abstract]2021 Dec 8;53(12):1662-1669. PMID: 34718375 -
J Diabetes Res
Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway. [Abstract]2020 Mar 26;2020:4326549. PMID: 32309446 -
Front Oncol
Targeting the lncRNA DUXAP8/miR-29a/ PIK3CA Network Restores Doxorubicin Chemosensitivity via PI3K-AKT-mTOR Signaling and Synergizes With Inotuzumab Ozogamicin in Chemotherapy-Resistant B-Cell Acute Lymphoblastic Leukemia. [Abstract]2022 Mar 2;12:773601. PMID: 35311115 -
Int J Med Sci
Betulin inhibits inflammatory factors synthesis in osteoarthritis synovial fibroblasts by suppressing the PI3K, Akt, and mTOR pathways and activating miR-5006-5p. [Abstract]2026 Mar 17;23(4):1567-1576. PMID: 41938515 -
Pathol Res Pract
Serine/arginine-rich splicing factor 1 inhibits ferroptosis and promotes glycolysis in endometrial cancer via activating mTOR and β-catenin. [Abstract]2026 Mar:279:156364. PMID: 41564687 -
Environ Toxicol
Calcitriol suppresses gastric cancer progression and cisplatin resistance by inhibiting glycolysis and M2 macrophage polarization through inhibition of mTOR activation. [Abstract]2024 Feb;39(2):830-839. PMID: 37792677 -
Cytotherapy
Mesenchymal stromal cells regulate THP-1-differentiated macrophage cytokine production by activating Akt/mammalian target of rapamycin complex 1 pathway. [Abstract]2023 Aug;25(8):858-865. PMID: 37125989 -
Environ Toxicol
Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. [Abstract]2023 Aug;38(8):1874-1890. PMID: 37148176 -
Int J Med Sci
AKR1B10 Inhibitor Epalrestat Facilitates Sorafenib-Induced Apoptosis and Autophagy Via Targeting the mTOR Pathway in Hepatocellular Carcinoma. [Abstract]2020 May 18;17(9):1246-1256. PMID: 32547320 -
Cell Biol Int
Overexpression of TRIM32 promotes pancreatic β-cell autophagic cell death through Akt/mTOR pathway under high glucose conditions. [Abstract]2022 Dec;46(12):2095-2106. PMID: 36040726 -
Discov Oncol
CDCA5 knockdown potentiates olaparib sensitivity in BRCA1-mutated ovarian cancer through autophagy activation. [Abstract]2025 Sep 30;16(1):1789. PMID: 41026320 -
Discov Oncol
2025 May 16;16(1):788. PMID: 40377756 -
J Pharmacol Sci
Cinnamaldehyde protects SH-SY5Y cells against advanced glycation end-products induced ectopic cell cycle re-entry. [Abstract]2024 Sep;156(1):1-8. PMID: 39068030 -
Carcinogenesis
miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway. [Abstract]2024 Feb 12;45(1-2):45-56. PMID: 37971062 -
Mol Brain
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression. [Abstract]2022 Jul 18;15(1):61. PMID: 35850767 -
Toxicol Lett
Low-dose cadmium exposure promotes osteoclastogenesis by enhancing autophagy via inhibiting the mTOR/p70S6K1 signaling pathway. [Abstract]2022 Aug 15:367:9-18. PMID: 35843418 -
Toxicol Lett
Targeting SLC1A5 blocks cell proliferation through inhibition of mTORC1 in arsenite-treated human uroepithelial cells. [Abstract]2021 Jul 1:345:1-11. PMID: 33781819 -
J Orthop Surg Res
Epimedium Brevicornu and Curculigo orchioides inhibit osteoclast autophagy by degrading the level of miRNA-199 to regulate the mTOR signaling pathway. [Abstract]2025 Jul 9;20(1):631. PMID: 40635043 -
J Cell Biochem
Cucurbitacin I induces pro-death autophagy in A549 cells via the ERK-mTOR-STAT3 signaling pathway. [Abstract]2018 Jul;119(7):6104-6112. PMID: 29575175
MHY1485 purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2018 Jul;119(7):6104-6112. [Abstract]
MHY-1485 significantly suppresses the increase in LC3II/LC3I ratios induced by Cucurbitacin I.
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Anal Cell Pathol
PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells. [Abstract]2026;2026(1):e3662809. PMID: 41810929 -
BMC Mol Cell Biol
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage. [Abstract]2024 Apr 23;25(1):13. PMID: 38654163 -
J Assist Reprod Genet
BNIP3-mediated autophagy via the mTOR/ULK1 pathway induces primordial follicle loss after ovarian tissue transplantation. [Abstract]2023 Mar;40(3):491-508. PMID: 36869237 -
Toxicol In Vitro
Autophagy induces mTOR-dependent glucose uptake and mTOR-independent lactate utilization in cadmium-treated A549 cells. [Abstract]2023 Feb:86:105513. PMID: 36336208 -
Virus Res
Repurposing of antiparasitic niclosamide to inhibit respiratory syncytial virus (RSV) replication. [Abstract]2021 Apr 2:295:198277. PMID: 33476693 -
Dig Dis Sci
Kaempferol Ameliorates Functional Constipation in Mice by Regulating Autophagy of Interstitial Cells of Cajal via the p53/AMPK/mTOR Axis. [Abstract]2025 Nov 15. PMID: 41240265 -
Cell Biochem Biophys
Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro. [Abstract]2025 Sep 27. PMID: 41014453 -
J Steroid Biochem Mol Biol
Nano-curcumin attenuates tamoxifen resistance and malignant progression in ER-positive breast cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. [Abstract]2025 Jul 3:254:106825. PMID: 40617262 -
World J Surg Oncol
DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy. [Abstract]2025 Apr 2;23(1):115. PMID: 40176057 -
Theriogenology
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway. [Abstract]2023 Dec:212:91-103. PMID: 37717519 -
Odontology
Rg1 activates the AMPK/mTOR-autophagy axis and inhibits the NOD-like receptor 3 inflammasome to alleviate pyroptosis in periodontal ligament fibroblasts. [Abstract]2026 Jan 23. PMID: 41572117 -
J Chin Med Assoc
FARSB downregulation by SPI1 modulates lung adenocarcinoma progression and immune microenvironment via mTOR pathway. [Abstract]2025 Sep 3. PMID: 40898930 -
Eur J Neurosci
Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia. [Abstract]2025 May;61(9):e70137. PMID: 40353431 -
PeerJ
Raptor couples mTORC1 and ERK1/2 inhibition by cardamonin with oxidative stress induction in ovarian cancer cells. [Abstract]2023 Jun 7:11:e15498. PMID: 37304865 -
Am J Reprod Immunol
Lipoxin A4 depresses inflammation and promotes autophagy via AhR/mTOR/AKT pathway to suppress endometriosis. [Abstract]2023 Mar;89(3):e13659. PMID: 36412044 -
J Oral Pathol Med
miR-134-3p Deficiency-Induced Methionine Metabolism Promotes Fibrosis via SLC25A33 in OSF. [Abstract]2025 Aug;54(7):584-596. PMID: 40580027 -
Exp Ther Med
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1‑autophagy axis. [Abstract]2024 Apr 15;27(6):252. PMID: 38682112 -
Biochem Biophys Res Commun
Purpurogallin improves septic coagulopathy and hepatic injury through inhibiting AKT/mTOR/STAT3 signaling pathway. [Abstract]2026 May 21:814:153669. PMID: 41887076 -
Arch Oral Biol
Peroxiredoxin 1 inhibits autophagy through interacting with Rab7 in human dysplastic oral keratinocyte cells. [Abstract]2022 Sep:141:105491. PMID: 35797840 -
J Stomatol Oral Maxillofac Surg
Protective role of interleukin-37 in oral lichen planus: Regulation of Jurkat cell glycolysis through the mTOR pathway. [Abstract]2025 Jul 25:102511. PMID: 40714261 -
Neurosci Lett
Ephrin-B2 inhibits Aβ25-35-induced apoptosis by alleviating endoplasmic reticulum stress and promoting autophagy in HT22 cells. [Abstract]2019 Jun 21:704:50-56. PMID: 30936033 -
Biomed Rep
Resveratrol ameliorates high‑fat diet‑induced insulin resistance via the DDIT4/mTOR pathway in skeletal muscle. [Abstract]2025 Apr 14;22(6):99. PMID: 40297802 -
J Interferon Cytokine Res
2025 Oct;45(10):335-343. PMID: 40916805 -
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Biol Pharm Bull
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR signaling Pathways. [Abstract]2024 Feb 22;47(2):486-498. PMID: 38199251 -
Neuroreport
All-trans retinoic acid reduces mammalian target of rapamycin via a Sirtuin1-dependent mechanism in neurons. [Abstract]2021 Aug 11;32(12):975-982. PMID: 34050114 -
Open Life Sci
2019 Aug 28:14:400-409. PMID: 33817175 -
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J Vis Exp
Effects of Moist Exposed Burn Ointment on Wound Neovascularization and Plasma Exosomal mir-31-5p in Diabetic Mice. [Abstract]2025 Aug 26:(222). PMID: 40952992 -
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Ann Transl Med
Jian Pi Tiao Gan Yin alleviates obesity phenotypes through mTORC1/SREBP1 signaling in vitro and in vivo. [Abstract]2022 Mar;10(6):291. PMID: 35433951 -
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Oncotarget
2017 Feb 21;8(8):12775-12783. PMID: 28061443
MHY1485 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Feb 21;8(8):12775-12783. [Abstract]
OSI-027, AZD-8055 and AZD-2014 almost completely block MHY1485-induced mTOR activation (p-mTOR/S6K1/Akt Ser473) in skin keratinocytes.
Solvent & Solubility
DMSO : 7 mg/mL (18.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : < 1 mg/mL (insoluble)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.77 mg/mL (1.99 mM); Clear solution
This protocol yields a clear solution of ≥ 0.77 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (7.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Gao L, et al. Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation. Cancer Lett. 2019 Jul 10;454:215-223. [Content Brief]
[2]. Choi YJ, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7(8):e43418. [Content Brief]
[3]. Zhou J, et al.Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells.Cell Death Dis. 2017 Aug 17;8(8):e3001. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5814 mL | 12.9069 mL | 25.8138 mL | 64.5344 mL |
| 5 mM | 0.5163 mL | 2.5814 mL | 5.1628 mL | 12.9069 mL | |
| 10 mM | 0.2581 mL | 1.2907 mL | 2.5814 mL | 6.4534 mL | |
| 15 mM | 0.1721 mL | 0.8605 mL | 1.7209 mL | 4.3023 mL |
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