1. Metabolic Enzyme/Protease
  2. Pyruvate Kinase

Pyruvate Kinase

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms (PKM1, PKM2, PKR, PKL), and each isoform has had multiple designations over time in the literature. The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue. The enzymatic activity of PKM2 is allosterically regulated by both intracellular signaling pathways and metabolites; PKM2 thus integrates signaling and metabolic inputs to modulate glucose metabolism according to the needs of the cell.

Pyruvate Kinase Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-18657
    TEPP-46 Activator 99.56%
    TEPP-46 is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR.
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin has shown various biological activities, including inhibition of TNF-α, NF-κB, HIV-1.
  • HY-19330
    DASA-58 Activator 98.01%
    DASA-58 is a potent activator of pyruvate kinase M2 (PKM2) with an AC90 of 680 nM, and an AC50 of 38 nM.
  • HY-103617
    PKM2-IN-1 Inhibitor 98.35%
    PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM.
  • HY-12689
    Mitapivat Activator 99.72%
    Mitapivat is a pyruvate kinase isoenzyme M2 (PKM2) activator.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.