PKL-IN-1
Based on 1 Customer Validation
PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease.
For research use only. We do not sell to patients.
- Purity: 99.29%
- CAS No.: 3078059-66-9
- Formula: C12H8O8S
- Molecular Weight:312.25
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.07 μM (PKL)[1]
PKL-IN-1 (Compound 12a) (10 μM; 5 min) inhibits PKL activity by 96.6%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3078059-66-9
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Appearance Solid
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Molecular Weight 312.25
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Formula C12H8O8S
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Color White to off-white
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SMILES
OC1=C(O)C=C(C(C(O)=C(O)C(O)=C2)=C2OS3(=O)=O)C3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (400.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2026 mL | 16.0128 mL | 32.0256 mL | 80.0641 mL |
| 5 mM | 0.6405 mL | 3.2026 mL | 6.4051 mL | 16.0128 mL | |
| 10 mM | 0.3203 mL | 1.6013 mL | 3.2026 mL | 8.0064 mL | |
| 15 mM | 0.2135 mL | 1.0675 mL | 2.1350 mL | 5.3376 mL | |
| 20 mM | 0.1601 mL | 0.8006 mL | 1.6013 mL | 4.0032 mL | |
| 25 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2026 mL | |
| 30 mM | 0.1068 mL | 0.5338 mL | 1.0675 mL | 2.6688 mL | |
| 40 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0016 mL | |
| 50 mM | 0.0641 mL | 0.3203 mL | 0.6405 mL | 1.6013 mL | |
| 60 mM | 0.0534 mL | 0.2669 mL | 0.5338 mL | 1.3344 mL | |
| 80 mM | 0.0400 mL | 0.2002 mL | 0.4003 mL | 1.0008 mL | |
| 100 mM | 0.0320 mL | 0.1601 mL | 0.3203 mL | 0.8006 mL |
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