1. Neuronal Signaling
  2. CaMK

CaMK

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

CaMK Related Products (19):

Cat. No. Product Name Effect Purity
  • HY-15465
    KN-93 Inhibitor 98.79%
    KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.
  • HY-19805
    STO-609 Inhibitor >98.0%
    STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively.
  • HY-15465B
    KN-93 phosphate Inhibitor 99.91%
    KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
  • HY-13290
    KN-62 Inhibitor 99.16%
    KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM. KN-62 is also a noncompetitive antagonist of P2X7 receptor, with an IC50 of app
  • HY-15517B
    KN-92 hydrochloride Inhibitor 99.77%
    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
  • HY-P0214A
    Autocamtide-2-related inhibitory peptide TFA Inhibitor 98.48%
    Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM. Sequence: Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu;KKALRRQEAVDAL.
  • HY-110096
    A-484954 Inhibitor 98.01%
    A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM.
  • HY-100779
    Rimacalib Inhibitor
    Rimacalib is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.
  • HY-15465A
    KN-93 hydrochloride Inhibitor 99.67%
    KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.
  • HY-15517A
    KN-92 phosphate Inhibitor 99.94%
    KN-92 is an inactive derivative of KN-93.
  • HY-18271
    CaMKII-IN-1 Inhibitor 98.09%
    CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
  • HY-P1029
    MLCK inhibitor peptide 18 Inhibitor 98.71%
    MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Sequence: Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2;RKKYKYRRK-NH2.
  • HY-P0225
    Autocamtide 2 98.17%
    Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Sequence: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu;KKALRRQETVDAL.
  • HY-15517
    KN-92 Inhibitor
    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
  • HY-P1479
    Calmodulin-Dependent Protein Kinase II 290-309 Antagonist
    Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Sequence: Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala;LKKFNARRKLKGAILTTMLA.
  • HY-P1528
    Autocamtide 2, amide
    Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Sequence: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-NH2;KKALRRQETVDAL-NH2.
  • HY-100263
    Metofenazate Inhibitor
    Metofenazate is a selective calmodulin inhibitor.
  • HY-100576
    NH125 Inhibitor >98.0%
    NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also could induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K.
  • HY-P0271
    Syntide 2
    Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM. Sequence: Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys;PLARTLSVAGLPGKK.
Isoform Specific Products

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