1. Epigenetics TGF-beta/Smad Neuronal Signaling Metabolic Enzyme/Protease Apoptosis
  2. PKC CaMK Phosphatase Apoptosis
  3. DCP-LA

DCP-LA  (Synonyms: FR236924)

Cat. No.: HY-108599 Purity: ≥98.0%
COA Handling Instructions

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

For research use only. We do not sell to patients.

DCP-LA Chemical Structure

DCP-LA Chemical Structure

CAS No. : 28399-31-7

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 112 In-stock
Solution
10 mM * 1 mL in DMSO USD 112 In-stock
Liquid
1 mg USD 99 In-stock
5 mg USD 165 In-stock
10 mg USD 231 In-stock
25 mg USD 462 In-stock
50 mg USD 792 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].

IC50 & Target[1][3]

PKCε

 

CaMK II

 

In Vitro

DCP-LA (100 nM; 15 min) activates cytosolic PKCε by binding to the phosphatidylserine binding/associating sites Arg50 and Ile89, without translocation towards the cell surface in PL-12 cells[1].
DCP-LA (10, 100, 100 nM; 10 min; 35 ℃) activates CaMKII and inhibits PP-1 in rat hippocampal neurons[2].
DCP-LA (100 nM; 20 min) increases expression of the receptors on the plasma membrane, responsible for potentiate AMPA receptor responses in rat hippocampal slices[2].
DCP-LA (100 nM; 10 min) results facilitation of hippocampal synaptic transmission[2].
DCP-LA (100 nM; 24 h) prevents the Sodium nitroprusside (SNP, HY-10219) effect and rescues neurons from SNP-induced degradation[3].
DCP-LA (100 nM; 12 h) abolishes the caspase-3/9 activation induced by (SNP, HY-10219) (1 mM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Rat cerebral cortical neurons
Concentration: 100 nM
Incubation Time: 24 hours; accompanied with 1 mM Sodium nitroprusside (SNP)
Result: Prevented SNP-induced neuronal cell death.
In Vivo

DCP-LA (1 mg/kg; p.o.; once daily; 7 d) exhibits a protective effect against ischemic brain damage, decreasing cerebral cortical defect due to middle cerebral artery (MCA) occlusion in mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery (MCA) occlusion in mouse model (male CB-17 mice, 5-8 weeks old)[3]
Dosage: 1 mg/kg
Administration: Oral gavage; once daily for 7 days; sacrificed mice on days 28
Result: Significantly diminished degraded area due to cerebral infarction, with the rescued area reaching 82%.
Molecular Weight

308.50

Formula

C20H36O2

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2415 mL 16.2075 mL 32.4149 mL
5 mM 0.6483 mL 3.2415 mL 6.4830 mL
10 mM 0.3241 mL 1.6207 mL 3.2415 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 0.5 mg/mL (1.62 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 0.5 mg/mL (1.62 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DCP-LA
Cat. No.:
HY-108599
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