1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCθ Isoform

PKCθ

 

PKCθ Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-10343
    Sotrastaurin
    Inhibitor 99.89%
    Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
  • HY-15727
    Afuresertib
    Inhibitor 99.54%
    Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively.
  • HY-112782
    VTX-27
    Inhibitor 99.64%
    VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ.
  • HY-101569
    Darovasertib
    Inhibitor 99.68%
    Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively.
  • HY-15727A
    Afuresertib hydrochloride
    Inhibitor 99.03%
    Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.
  • HY-112681
    PKC-theta inhibitor
    Inhibitor 99.75%
    PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.
  • HY-132304
    CC-90005
    Inhibitor 99.98%
    CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM.
  • HY-108264
    TCS 21311
    Inhibitor 99.18%
    TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2.
  • HY-126328
    PKC-theta inhibitor 1
    Inhibitor
    PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM.
  • HY-139467
    PF-04577806
    Inhibitor
    PF-04577806 is a potent, selective and ATP competitive PKC inhibitor.
  • HY-12663
    AS2521780
    Inhibitor
    AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.
  • HY-139466
    PF-03622905
    Inhibitor
    PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively.