1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
    TGF-beta/Smad
    PI3K/Akt/mTOR
  2. JAK
    PKC
    GSK-3
  3. TCS 21311

TCS 21311 (Synonyms: NIBR3049)

Cat. No.: HY-108264 Purity: >98.0%
Handling Instructions

TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.

For research use only. We do not sell to patients.

TCS 21311 Chemical Structure

TCS 21311 Chemical Structure

CAS No. : 1260181-14-3

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1].

IC50 & Target[1]

JAK3

8 nM (IC50)

JAK2

2.55 μM (IC50)

JAK1

1.017 μM (IC50)

PKCα

13 nM (IC50)

PKCθ

68 nM (IC50)

GSK-3β

3 nM (IC50)

In Vitro

TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay[1].
TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity[1].

Molecular Weight

526.51

Formula

C₂₇H₂₅F₃N₄O₄

CAS No.

1260181-14-3

SMILES

O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

TCS 21311NIBR3049TCS21311TCS-21311NIBR 3049NIBR-3049JAKPKCGSK-3Janus kinaseProtein kinase CGlycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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TCS 21311
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