1260181-14-3
1260181-14-3
Chemical Structure
TCS 21311
Synonym(s): NIBR3049
- CAS No.: 1260181-14-3
- Formula:C27H25F3N4O4
- Molecular Weight:526.51
IUPAC Name: 3-(5-(4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
InChIKey: CLGRAWDGLMENOD-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O
Biological Activity: TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TCS 21311 | 99.49% | TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively. | ||||||||||||||||||||
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TCS 21311 (Standard) | ≥98% | TCS 21311 (Standard) is the analytical standard of TCS 21311 (HY-108264). This product is intended for research and analytical applications. TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively. | ||||||||||||||||||||
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