1. Signaling Pathways
  2. Epigenetics
    JAK/STAT Signaling
    Stem Cell/Wnt
  3. JAK
  4. Tyk2 Inhibitors

Tyk2 Inhibitors

JAK1

JAK2

JAK3

Tyk2

JAK

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Sorry. There is currently no product that acts on isoform Tyk2 together.

Please try each isoform separately.

Tyk2 Specific Inhibitors
Product Name Tyk2 JAK1 JAK2 JAK3 Tyk2 Selectivity Purity
Cerdulatinib
Tyk2, IC50: 0.5 nM
JAK1, IC50: 12 nM
JAK2, IC50: 6 nM
JAK3, IC50: 8 nM
Selective Inhibitor 99.00%
SAR-20347
Tyk2, IC50: 0.6 nM
JAK1, IC50: 23 nM
JAK2, IC50: 26 nM
JAK3, IC50: 41 nM
Selective Inhibitor 97.00%
TyK2-IN-2
Tyk2
      Selective Inhibitor 99.41%
Tyk2-IN-5
Tyk2 JH2, Ki: 0.086 nM
      Selective Inhibitor 99.78%
Tyk2-IN-7
Tyk2 JH2, IC50: 0.00053 μM
Tyk2 JH2, Ki app: 0.00007 μM
      Selective Inhibitor
Ruxolitinib
Tyk2, IC50: 19 nM
JAK1, IC50: 3.3 nM
JAK2, IC50: 2.8 nM
JAK3, IC50: 428 nM
Pan Inhibitor 99.99%
Ruxolitinib phosphate
Tyk2, IC50: 19 nM
JAK1, IC50: 3.3 nM
JAK2, IC50: 2.8 nM
JAK3, IC50: 428 nM
Pan Inhibitor 99.89%
Baricitinib
Tyk2, IC50: 53 nM
JAK1, IC50: 5.9 nM
JAK2, IC50: 5.7 nM
JAK3, IC50: 560 nM
Pan Inhibitor 99.93%
BMS-986165
Tyk2 JH2, IC50: 0.2 nM
JAK1 JH2, IC50: 1 nM
    Pan Inhibitor 99.76%
Pacritinib
Tyk2, IC50: 50 nM
JAK1, IC50: 1280 nM
JAK2V617F, IC50: 19 nM
JAK2wt, IC50: 23 nM
JAK3, IC50: 520 nM
Pan Inhibitor 99.66%
Filgotinib
Tyk2, IC50: 116 nM
JAK1, IC50: 10 nM
JAK2, IC50: 28 nM
JAK3, IC50: 810 nM
Pan Inhibitor 99.64%
Peficitinib
Tyk2, IC50: 4.8 nM
JAK1, IC50: 3.9 nM
JAK2, IC50: 5 nM
JAK3, IC50: 0.7 nM
Pan Inhibitor 99.43%
Gandotinib
Tyk2, IC50: 44 nM
 
JAK2, IC50: 3 nM
JAK3, IC50: 48 nM
Pan Inhibitor 99.96%
Pyridone 6
Tyk2, IC50: 1 nM
Murine JAK1, IC50: 15 nM
JAK2, IC50: 1 nM
JAK3, IC50: 5 nM
Pan Inhibitor 98.04%
Delgocitinib
Tyk2, IC50: 58 nM
JAK1, IC50: 2.8 nM
JAK2, IC50: 2.6 nM
JAK3, IC50: 13 nM
Pan Inhibitor 99.14%
Oclacitinib maleate
Tyk2, IC50: 84 nM
JAK1, IC50: 10 nM
JAK2, IC50: 18 nM
JAK3, IC50: 99 nM
Pan Inhibitor 99.53%
Abrocitinib
Tyk2, IC50: 1253 nM
JAK1, IC50: 29 nM
JAK2, IC50: 803 nM
  Pan Inhibitor 99.79%
BMS-911543
Tyk2, IC50: 66 nM
JAK1, IC50: 75 nM
JAK2, IC50: 1.1 nM
JAK3, IC50: 360 nM
Pan Inhibitor 98.12%
Ilginatinib
Tyk2, IC50: 22 nM
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Pan Inhibitor 95.88%
Baricitinib phosphate
Tyk2, IC50: 53 nM
JAK1, IC50: 5.9 nM
JAK2, IC50: 5.7 nM
JAK3, IC50: 560 nM
Pan Inhibitor 99.49%
NVP-BSK805 dihydrochloride
TYK2 JH1, IC50: 10.76 nM
JAK1 JH1, IC50: 31.63 nM
JAK2 JH1, IC50: 0.48 nM
FL JAK2 V617F, IC50: 0.56 nM
FL JAK2 wt, IC50: 0.58 nM
JAK3 JH1, IC50: 18.68 nM
Pan Inhibitor 99.36%
Decernotinib
Tyk2, Ki: 11 nM
JAK1, Ki: 11 nM
JAK2, Ki: 13 nM
JAK3, Ki: 2.5 nM
Pan Inhibitor 98.91%
Ilginatinib maleate
Tyk2, IC50: 22 nM
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Pan Inhibitor 97.04%
JAK/HDAC-IN-1
Tyk2, IC50: 49 nM
JAK1, IC50: 4.8 nM
JAK2, IC50: 4 nM
JAK3, IC50: 7.4 nM
Pan Inhibitor 98.04%
Ilginatinib hydrochloride
Tyk2, IC50: 22 nM
JAK1, IC50: 33 nM
JAK2, IC50: 0.72 nM
JAK3, IC50: 39 nM
Pan Inhibitor 98.02%
GLPG0634 analog
Tyk2, IC50: <100 nM
   
JAK3, IC50: <100 nM
Pan Inhibitor 98.00%
NVP-BSK805
TYK2 JH1, IC50: 10.76 nM
JAK1 JH1, IC50: 31.63 nM
JAK2 JH1, IC50: 0.48 nM
FL JAK2 V617F, IC50: 0.56 nM
FL JAK2 wt, IC50: 0.58 nM
JAK3 JH1, IC50: 18.68 nM
Pan Inhibitor
PF-06263276
Tyk2, IC50: 29.7 nM
JAK1, IC50: 2.2 nM
JAK2, IC50: 23.1 nM
JAK3, IC50: 59.9 nM
Pan Inhibitor
JAK-IN-3
Tyk2, IC50: 34 nM
JAK1, IC50: 5 nM
JAK2, IC50: 70 nM
JAK3, IC50: 3 nM
Pan Inhibitor
BMS-066
Tyk2, IC50: 72 nM
      Pan Inhibitor
Ruxolitinib sulfate
Tyk2, IC50: 19 nM
JAK1, IC50: 3.3 nM
JAK2, IC50: 2.8 nM
JAK3, IC50: 428 nM
Pan Inhibitor