944118-01-8
944118-01-8
Chemical Structure
Peficitinib
Synonym(s): ASP015K; JNJ-54781532
- CAS. Nr.: 944118-01-8
- Formula:C18H22N4O2
- Molecular Weight:326.39
IUPAC Name: 4-(((1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
InChIKey: DREIJXJRTLTGJC-ZKVNVPQCSA-N
SMILES: O[C@](C[C@@H]1C[C@H]2C3)(C2)C[C@@H]3[C@H]1NC4=C5C(NC=C5)=NC=C4C(N)=O
Biological Activity: Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Peficitinib | 99.38% | Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. | ||||||||||||||||||||
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Peficitinib (Standard) | 99.53% | Peficitinib (Standard) is the analytical standard of Peficitinib. This product is intended for research and analytical applications. Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. | ||||||||||||||||||||
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Peficitinib-d3 | Peficitinib-d3 (ASP015K-d3) is the deuterium labeled Peficitinib (HY-19568). Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-19568APeficitinib hydrobromide -
Similarity Score 0.98
HY-19568BPeficitinib hydrochloride -
Similarity Score 0.66
HY-149296JAK1-IN-12 -
Similarity Score 0.50
HY-176793Embricitinib -
Similarity Score 0.49
HY-161015JAK1-IN-13 -
Similarity Score 0.49
HY-156621Lepzacitinib -
Similarity Score 0.47
HY-183451Y-30141 -
Similarity Score 0.42
HY-163769DUB-IN-8 -
Similarity Score 0.42
HY-112198AZ31 -
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