DEP-1/CD148
CD148, better known as DEP-1 or the PTPRJ phosphatase, is a receptor-type protein tyrosine phosphatase whose extracellular segment carries multiple fibronectin type III repeats and whose abundance rises with cell density. This density dependence underlies its role as a brake on endothelial and epithelial growth: DEP-1 dephosphorylates receptor tyrosine kinases such as VEGFR2, restraining angiogenic and mitogenic signaling. In platelets, the enzyme modulates adhesive signaling through partners including PECAM-1. Loss of heterozygosity and allelic variants of PTPRJ on chromosome 11p11 have been linked to colorectal and breast cancer susceptibility, establishing CD148 as a candidate tumor suppressor. Recombinant CD148 serves phosphatase and vascular signaling studies.
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DEP-1/CD148 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
