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Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor Related Products (21):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.67%
    Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
  • HY-B0469
    Medroxyprogesterone acetate Agonist 99.82%
    Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
  • HY-N0437
    Progesterone Agonist 99.46%
    Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal (acetate) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
  • HY-B0257A
    Dydrogesterone Agonist 99.98%
    Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
  • HY-W011890
    Cridanimod Activator 99.82%
    Cridanimod is a small-molecule immunomodulator and interferon inducer. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression.
  • HY-105634A
    Nomegestrol acetate Agonist
    Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
  • HY-105634
    Nomegestrol Agonist
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
  • HY-13676
    Megestrol Acetate Inhibitor >98.0%
    Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.
  • HY-B0111
    Drospirenone Agonist 98.45%
    Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.
  • HY-15606
    Tanaproget Agonist 98.99%
    Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
  • HY-B0084
    Dienogest Agonist 99.70%
    Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis.
  • HY-B1095
    Chlormadinone acetate Agonist >98.0%
    Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
  • HY-B1710
    Norethindrone acetate 99.33%
    Norethindrone acetate is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
  • HY-12516
    Desogestrel Agonist 99.33%
    Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).
  • HY-13071
    Nestoron Agonist 99.41%
    Nestoron (Elcometrine) is a 19-norprogesterone derivative with high affinity and selectivity for progesterone receptors. Nestoron is a highly selective and potent progestogen that can be used as a hormonal contraceptive.
  • HY-B1089
    Ethynodiol diacetate Agonist 98.02%
    Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.
  • HY-119433
    Asoprisnil Modulator 98.30%
    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.
  • HY-B0110
    Gestodene Agonist 99.86%
    Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive.
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