1. Signaling Pathways
  2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (74):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone
    Antagonist 99.77%
    Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
  • HY-N0437
    Progesterone
    Agonist 99.42%
    Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-B0469
    Medroxyprogesterone acetate
    Agonist 99.88%
    Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
  • HY-B0648
    Medroxyprogesterone
    Agonist 99.30%
    Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
  • HY-B0891
    17α-Hydroxyprogesterone
    Agonist 99.96%
    17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
  • HY-N0437R
    Progesterone (Standard)
    Agonist
    Progesterone (Standard) is the analytical standard of Progesterone. This product is intended for research and analytical applications. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-B0554R
    Norethindrone (Standard)
    Agonist
    Norethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
  • HY-106827
    Trimegestone
    Inhibitor
    Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
  • HY-13676
    Megestrol acetate
    Inhibitor 98.59%
    Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
  • HY-B0257
    Levonorgestrel
    Agonist 99.88%
    Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
  • HY-B0084
    Dienogest
    Agonist 99.90%
    Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
  • HY-B0554
    Norethindrone
    Agonist 99.37%
    Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
  • HY-B0257A
    Dydrogesterone
    Agonist 99.88%
    Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
  • HY-B0111
    Drospirenone
    Agonist 98.45%
    Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
  • HY-W011890
    Cridanimod
    Activator 99.97%
    Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.
  • HY-15606
    Tanaproget
    Agonist 99.87%
    Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
  • HY-16508
    Ulipristal acetate
    Antagonist 99.89%
    Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
  • HY-11028
    PF-02413873
    Antagonist 99.29%
    PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.
  • HY-B1095
    Chlormadinone acetate
    Agonist ≥98.0%
    Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
  • HY-B2245
    Estradiol dipropionate
    Agonist 99.85%
    Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and progesterone agonist.