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  3. Norethindrone

Norethindrone (Synonyms: Norethisterone)

Cat. No.: HY-B0554 Purity: 99.11%
Handling Instructions

Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

For research use only. We do not sell to patients.

Norethindrone Chemical Structure

Norethindrone Chemical Structure

CAS No. : 68-22-4

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Based on 1 publication(s) in Google Scholar

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Description

Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

IC50 & Target

Progesterone Receptor[1]

In Vivo

Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief[1]. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back[2]. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology[3]. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats[4].

Molecular Weight

298.42

Formula

C₂₀H₂₆O₂

CAS No.

68-22-4

SMILES

C[[email protected]@]1([[email protected]]2(O)C#C)[[email protected]](CC2)([H])[[email protected]@](CCC3=CC4=O)([H])[[email protected]]([[email protected]@]3([H])CC4)([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Animal Administration
[4]

Rats: Female Sprague-Dawley rats (200-210 g), 6 of which serve as controls, are individually caged in an animal room illuminated from 9:00 a.m. to 9:00 p.m. Each of the 7 rats receiving norethindrone acetate is fed 35 μg/day for 2 weeks. Water and the rat chow which is high in carbohydrate are available ad libitum[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.11%

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Keywords:

NorethindroneNorethisteroneProgesterone ReceptorNR3C3Inhibitorinhibitorinhibit

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