Pseudokinases

Cat. No.	Product Name / Synonyms	Species	Source	Image

HY-P73390

ROR1 Protein, Human (sf9, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1	Human	Sf9 insect cells
ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74491

TRIB3 Protein, Human (sf9, GST) Tribbles homolog 3; TRB-3; SINK; C20orf97; NIPK; SKIP3	Human	Sf9 insect cells
TRIB3 protein is an inactive kinase that centrally regulates the integrated stress response (ISR) and inhibits DDIT3/CHOP transcriptional activity. It causes DDIT3/CHOP-dependent cell death during endoplasmic reticulum (ER) stress, particularly in programmed neuronal cell death. TRIB3 Protein, Human (sf9, GST) is the recombinant human-derived TRIB3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P78739

JAK1 Protein, Human (Inactive, sf9, His) JAK1; JAK-1; JAK1A; JAK1B; Jak1	Human	sf9 insect cells
JAK1 protein is a non-receptor tyrosine kinase that plays a crucial role in IFN-α/β/γ signaling and serves as a kinase partner for IL-2 and IL-10 receptors. It cooperates with the type I interferon receptor IFNAR2 to phosphorylate and activate IFNAR2 upon interferon binding to IFNAR1-IFNAR2. JAK1 Protein, Human (Inactive, sf9, His) is the recombinant human-derived JAK1 protein, expressed by sf9 insect cells , with N-His labeled tag.

(1)

HY-P702574

MLKL Protein, Human (His) hMLKL; Mixed lineage kinase domain like	Human	E. coli
MLKL protein is a pseudokinase that plays a key role in TNF-induced necroptosis. Despite lacking intrinsic kinase activity, it is activated through RIPK3 phosphorylation, leading to homotrimerization, plasma membrane localization, and execution of necroptosis. MLKL Protein, Human (His) is the recombinant human-derived MLKL protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74893

HER3 Protein, Human (sf9, His-GST) Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3	Human	Sf9 insect cells
HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (sf9, His-GST) is the recombinant human-derived HER3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P705709

Janus kinase 2/JAK2 Protein, Human (Inactive, V617F, sf9, StrepII, His, Avi) Tyrosine-protein kinase JAK2; EC:2.7.10.2; Janus kinase 2 (JAK-2); JAK2	Human	Sf9 insect cells

HY-P705710

JAK3 Protein, Human (Biotinylated, Inactive, sf9, Avi-His) Tyrosine-protein kinase JAK3; EC:2.7.10.2; Janus kinase 3 (JAK-3); Leukocyte janus kinase (L-JAK); JAK3	Human	Sf9 insect cells

HY-P74492

TRIB2 Protein, Human (sf9, His-GST) Tribbles homolog 2; TRB-2; TRIB2; TRB2	Human	Sf9 insect cells
TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

HY-P701725

VRK3 Protein, Human (sf9, His, GST) VRK3; Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia-related kinase 3	Human	Sf9 insect cells
Despite its inactive kinase state, VRK3 protein crucially regulates ERK activity by enhancing the phosphatase activity of DUSP3. The interaction with DUSP3 is pivotal as it dephosphorylates and inactivates ERK in the nucleus. VRK3, also interacting with the small GTPase RAN, forms a network of molecular interactions, positioning it as a key modulator in signaling pathways controlling ERK activity and nuclear cellular processes. VRK3 Protein, Human (sf9, His, GST) is the recombinant human-derived VRK3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P703637

PEAK1 Protein, Human (sf9, His, GST) KIAA2002	Human	Sf9 insect cells
PEAK1 Protein, Human (sf9, His, GST) is the recombinant human-derived PEAK1, expressed by sf9 insect cells , with His, GST labeled tag. ,

HY-P704967

TYK2 Protein, Human (Inactive, sf9, His) TYK2; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; JTK1	Human	sf9 insect cells

HY-P705808

Janus kinase 2/JAK2 Protein, Human (Inactive, Biotinylated, V617F, sf9, Avi) JAK2, Janus kinase 2	Human	sf9 insect cells

HY-P705809

TYK2 Protein, Human (Inactive, sf9, His-Avi) TYK2; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; JTK1	Human	sf9 insect cells

HY-P705810

TYK2 Protein, Human (Inactive, Biotinylated, sf9, His-Avi) TYK2; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; JTK1	Human	sf9 insect cells

HY-P705851

MLKL Protein, Human (sf9, His-GST) hMLKL; Mixed lineage kinase domain like	Human	sf9 insect cells

HY-P705877

ROR1 Protein, Human (sf9) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Ig-like domain; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1	Human	sf9 insect cells

HY-P705878

ROR1 Protein, Human (Inactive, sf9, His-GST) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Ig-like domain; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1	Human	sf9 insect cells

HY-P705879

ROR2 Protein, Human (Inactive, sf9, His-GST) Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2; ROR2; NTRKR2	Human	sf9 insect cells

HY-P705947

TYK2 Protein, Human (Active, sf9, GST) TYK2; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; JTK1	Human	Sf9 insect cells
TYK2 Protein, Human (Active, sf9, GST) is the recombinant human-derived TYK2 protein, expressed by Sf9 insect cells, with N-His tag.

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