G-CSF R
Granulocyte colony-stimulating factor receptor (G-CSFR, CSF3R, CD114) is a single-pass type I transmembrane protein of the class I cytokine receptor superfamily, expressed on neutrophils and their bone marrow progenitors, monocytes and endothelial cells. Ligand binding triggers homodimerization and activation of JAK/STAT, SRC-MAPK and PI3K-AKT cascades, with STAT3 being the dominant mediator of G-CSF-driven granulopoiesis. G-CSFR signaling directs proliferation, differentiation and survival of granulocytic precursors, mobilizes hematopoietic stem cells from bone marrow into peripheral blood, and enhances neutrophil chemotaxis, phagocytosis and oxidative burst. Clinically, G-CSF acting through this receptor is indispensable for chemotherapy-induced neutropenia management and stem cell harvest for transplantation. Acquired CSF3R mutations in severe congenital neutropenia drive progression to acute myeloid leukemia, and CSF3R variants define a distinct subtype of chronic neutrophilic leukemia.
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G-CSF R Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
