CD158b2/KIR2DL3
CD158b2, known as KIR2DL3, is the inhibitory KIR recognizing the C1 group of HLA-C molecules (allotypes bearing asparagine 80). KIR2DL3 is a two Ig-domain receptor with two cytoplasmic ITIM motifs that, upon engagement by C1 HLA-C, recruits SHP phosphatases to inhibit NK-cell degranulation and cytokine production, forming part of the 'missing-self' detection system. Compared with its allelic counterpart KIR2DL2, KIR2DL3 binds C1 ligands with lower affinity, and the two genes are mutually exclusive alleles at the same locus on the KIR B versus A haplotype framework. A clinically important nuance is that in hematopoietic stem-cell transplantation with HLA-C mismatched donors, KIR2DL3-mediated inhibition requires higher HLA-C surface density than KIR2DL2, so KIR2DL3-positive donor NK cells facing C1-deficient leukemia can more readily mediate graft-versus-leukemia effects. KIR2DL3 is also the receptor through which hepatitis C virus-associated NK-cell education is shaped, protecting against persistence of infection in KIR2DL3/HLA-C1 compound genotypes.
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CD158b2/KIR2DL3 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
