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Target Protein Ligand Library

83 Cited Publications
Customer Review

Based on 83 publication(s) in Google Scholar

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 120 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

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  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
  • Target Protein Ligand Library Product Image
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Description & Advantages

•   A unique collection of 120 ligands for target protein of PROTAC, which can be used for PROTAC design.

•   A useful tool for PROTAC development.

•   Mainly target AR, ER, BTK, BET, and BCR-ABL.

•   More detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 120 ligands for target proteins of PROTAC supplied as pre-dissolved Solutions or Solid.

Solution: 115 compounds supplied in 10 mM solution, 5 compounds supplied in 2 mM solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage
-80°C
Shipping
Blue ice

Documentation

  • PDF
  • Excel
  • SDF
  • Manual

Composition

Ligands for Target Protein for PROTAC (120)

Epigenetic Reader Domain (16)

CDK (10)

Apoptosis (6)

Autophagy (6)

Histone Methyltransferase (6)

Androgen Receptor (5)

FKBP (5)

Btk (4)

STAT (4)

SWI/SNF Complex (4)

Bcl-2 Family (3)

Bcr-Abl (3)

Glutathione Peroxidase (3)

Histone Acetyltransferase (3)

Ligands for E3 Ligase (3)

PD-1/PD-L1 (3)

Anaplastic lymphoma kinase (ALK) (2)

Aurora Kinase (2)

CCR (2)

DNA/RNA Synthesis (2)

Endogenous Metabolite (2)

Estrogen Receptor/ERR (2)

Ferroptosis (2)

HDAC (2)

HSP (2)

IRAK (2)

NF-κB (2)

p38 MAPK (2)

Src (2)

STING (2)

Tau Protein (2)

α-synuclein (2)

Akt (1)

Amyloid-β (1)

APC (1)

c-Met/HGFR (1)

c-Myc (1)

Cannabinoid Receptor (1)

Drug Metabolite (1)

E1/E2/E3 Enzyme (1)

EGFR (1)

Enterovirus (1)

Eukaryotic Release Factor (eRF) (1)

FAK (1)

FLT3 (1)

Histone Demethylase (1)

HIV (1)

IKZF Family (1)

Itk (1)

JAK (1)

JNK (1)

MDM-2/p53 (1)

MEK (1)

Melatonin Receptor (1)

Microphthalmia Associated Transcription Factor (MITF) (1)

Microtubule/Tubulin (1)

Mitophagy (1)

Monoamine Oxidase (1)

Mps1 (1)

Na+/K+ ATPase (1)

Oct3/4 (1)

PANoptosis (1)

Parasite (1)

PARP (1)

PGE synthase (1)

Polo-like Kinase (PLK) (1)

Proteasome (1)

RAD51 (1)

ROS Kinase (1)

SF3B1 (1)

Sirtuin (1)

TREM receptor (1)

Tyrosinase (1)

ULK (1)

Virus Protease (1)

WDR5 (1)

YTHDF (1)

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USD 120
In-stock
Estimated to ship on August 31 More）
500 mg
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Consult sales personnel for more information
Bulk Inquiry
500 mg
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Consult sales personnel for more information
Bulk Inquiry
Estimated to ship on August 31 More）
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