TRAIL/CD253
TRAIL (CD253), encoded by TNFSF10, is a TNF superfamily cytokine that induces apoptosis selectively in many transformed cells while sparing most normal cells. It signals through the death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) and is counterbalanced by the decoy receptors DcR1, DcR2 and osteoprotegerin, a pattern that underlies its tumor selectivity. NK cells and activated T cells use TRAIL as an antiviral and antitumor cytotoxic mechanism, and hepatocytes are notable sensitive targets. Recombinant TRAIL and DR4/DR5 agonist antibodies have been extensively tested in oncology, although clinical efficacy has so far been limited by resistance mechanisms.
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TRAIL/CD253 Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
