2. Adjuvant
  3. Saponin Adjuvant

Saponin Adjuvant

Multiple saponins have been applied in vaccine adjuvants. Saponins possess a unique hemolytic effect that disrupts red blood cell membranes and have an auxiliary function in escaping endosomes. They are currently being developed for use in mRNA vaccines, ADC drugs, small nucleic acids, and other pharmaceuticals. AS01 is composed of two immunostimulants: MPLA and a lipid-based adjuvant derived from the triterpenoid glycoside (Quillaja saponaria 21, QS-21) purified from the bark extract of Quillaja saponaria Molina.

Saponin Adjuvant (11):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101092
    QS-21-Api 141256-04-4 99.73%
    QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
    QS-21-Api
  • HY-N3522
    Platycoside E 237068-41-6 99.40%
    Platycoside E is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specific IgG2a and IgG2b antibody in the ovalbumin (OVA)-immunized mice.
    Platycoside E
  • HY-101092A
    QS-21 98.76%
    QS-21 is a mixture of QS-21-Xyl (HY-101092B) and QS-21-Api (HY-101092), with a ratio of 35:65. QS-21 is an innate immune system-targeted adjuvant. QS-21 is promising for research of oncology vaccines (e.g., melanoma) and infectious disease vaccines (e.g., HIV, malaria).
    QS-21
  • HY-101092B
    QS-21-Xyl 250643-56-2
    QS-21-Xyl is a active component of QS-21 (HY-101092A). QS-21 is a natural vaccine adjuvant and induces a balanced Th1/Th2 immune response, particularly cellular immunity.
    QS-21-Xyl
  • HY-N2216
    Polygalasaponin XXXI 79103-90-5
    Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection.
    Polygalasaponin XXXI
  • HY-N9517
    QS 7 208933-54-4
    QS 7 (QS 7 Api) is a triterpene saponin found in the bark of Quillaja saponaria and immune adjuvant with immune response potentiator activity. QS 7 can be used as vaccine adjuvant for the research of antitumor and antiviral vaccine development.
    QS 7
  • HY-N16034
    MS 2 96552-96-4
    MS 2 (Momordica saponin II) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 2
  • HY-N15952
    MS 1 96552-95-3
    MS 1 (Momordica saponin I) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 1
  • HY-N15846
    VSA 1 2489675-55-8
    VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection.
    VSA 1
  • HY-N15770
    VSA 2 2489675-56-9
    VSA 2, a saponin-based vaccine adjuvant, is a derivative of Momordica saponin (MS) II. VSA 2 is an immunostimulant, shows consistent enhancement of immunoglobulin G2a (IgG2a) production when it was in formulation with either ovalbumin or recombinant hemagglutinin B (rHagB) antigen.
    VSA 2
  • HY-N16463
    QS-S2 250643-52-8
    QS-S2 is the impurity of QS-21 (HY-101092A). QS-21 is an innate immune system-targeted adjuvant.
    QS-S2