1. Anti-infection
  2. Influenza Virus
  3. Polygalasaponin XXXI

Polygalasaponin XXXI (Synonyms: Onjisaponin F)

Cat. No.: HY-N2216
Handling Instructions

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection.

For research use only. We do not sell to patients.

Polygalasaponin XXXI Chemical Structure

Polygalasaponin XXXI Chemical Structure

CAS No. : 79103-90-5

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Description

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].

In Vitro

Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1].
Polygalasaponin XXXI (Onjisaponin F) (1 or 10 µg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2].

In Vivo

Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1].

Molecular Weight

1589.67

Formula

C₇₅H₁₁₂O₃₆

CAS No.

79103-90-5

SMILES

OC[[email protected]](C([[email protected]]1([H])CC2(C)C)=CC[[email protected]]3([H])[[email protected]]4(C[[email protected]@H]5O)C)(CC[[email protected]]1(CC2)C(O[[email protected]](O[[email protected]@H]6C)[[email protected]@H]([[email protected]]([[email protected]]6OC(/C=C/C(C=C7OC)=CC(OC)=C7OC)=O)O)O[[email protected]](O[[email protected]]8C)[[email protected]@H]([[email protected]@H]([[email protected]]8O[[email protected]](OC[[email protected]]9O)[[email protected]@H]([[email protected]]9O[[email protected]](OC[[email protected]@H]%10O)[[email protected]@H]([[email protected]]%10O)O)O)O[[email protected]](OC[[email protected]@](O)%11CO)[[email protected]@H]%11O)O)=O)[[email protected]@]3(CC[[email protected]@]4([H])[[email protected]@](C)([[email protected]]5O[[email protected]@H]([[email protected]@H]([[email protected]]%12O)O)O[[email protected]@H]([[email protected]]%12O)CO)C(O)=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Polygalasaponin XXXIOnjisaponin FInfluenza VirusAdjuvantvaccineInfluenzaMucosalimmunityOnjisaponinPolygalatenuifoliaWilldenowPolygalaceaeInhibitorinhibitorinhibit

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