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  4. Polygalaceae

Polygalaceae

 

Polygalaceae (97):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0802
    Tenuigenin 2469-34-3 99.92%
    Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.
    Tenuigenin
  • HY-N0392
    Polygalasaponin F 882664-74-6 99.85%
    Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, caspase-3, NF-κB p65 and MEK1; restores and upregulates the expression of Bcl-2; activates the PI3K/Akt signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca2+ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimer's disease.
    Polygalasaponin F
  • HY-N0702
    Tenuifolin 20183-47-5 99.73%
    Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).
    Tenuifolin
  • HY-N2099
    Onjisaponin B 35906-36-6 99.31%
    Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB.
    Onjisaponin B
  • HY-W017100
    2-Hydroxy-6-methoxybenzoic acid 3147-64-6 99.34%
    2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) is an orally active derivative of Salicylic acid (HY-B0167). 2-Hydroxy-6-methoxybenzoic acid can be isolated from the plant Brickellia veronicifolia. 2-Hydroxy-6-methoxybenzoic acid has analgesic properties.
    2-Hydroxy-6-methoxybenzoic acid
  • HY-N19684
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl 136051-64-4
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl is a biphenyl compound found in Monnina obtusifolia. 3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl has antifungal activity.
    3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl
  • HY-N19646
    [8]-Dehydrogingerdione 77334-08-8
    [8]-Dehydrogingerdione is a Hydroxyphenylalkanone. [8]-Dehydrogingerdione can be isolated from the seeds of Aframomum melegueta and the rhizomes of Curcuma xanthorrhia. [8]-Dehydrogingerdione acts as an inhibitor of α-glucosidase and Tyrosinase, with an IC50 value of 19.5 μM against α-glucosidase and an approximate IC50 value of 100 μM against tyrosinase. [8]-Dehydrogingerdione can be used in diabetes-related research.
    [8]-Dehydrogingerdione
  • HY-N9628
    Polygalatenoside A 946839-55-0
    Polygalatenoside A is a noradrenaline reuptake inhibitor with an IC50 of 30.0 μM against human noradrenaline transporter. Polygalatenoside A can be used in the research of mental disorders.
    Polygalatenoside A
  • HY-W012123
    3,4,5-Trimethoxycinnamic acid 90-50-6 99.96%
    3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits.
    3,4,5-Trimethoxycinnamic acid
  • HY-N2263
    Skimmin 93-39-0 99.64%
    Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases.
    Skimmin
  • HY-N2167
    Sibiricose A5 107912-97-0 98.67%
    Sibiricose A5 is an oligosaccharide ester isolated from Polygalae Radix with potent antioxidant activity.
    Sibiricose A5
  • HY-N4279
    Gentisin 437-50-3 98.88%
    Gentisin is a natural compound. Gentisin can be extracted from Gentianae radix (Gentianaceae). Gentisin has mutagenic activity. Gentisin can be used in vascular smooth muscle research.
    Gentisin
  • HY-N2169
    Polygalasaponin V 162857-65-0 99.94%
    Polygalasaponin V is a triterpenoid saponin isolated from the aerial parts of Polygala japonica. Polygala japonica has been a folk medicine herb used as expectorant, anti-inflammatory, antibacterial and antidepressant agents in the south of China.
    Polygalasaponin V
  • HY-N1778
    3,4-Dimethoxycinnamic acid 2316-26-9 99.91%
    3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effects.
    3,4-Dimethoxycinnamic acid
  • HY-N8208
    Sibiricose A1 139726-40-2 99.46%
    Sibiricose A1is an oligosaccharide ester that can be found in Polygala tenuifolia.
    Sibiricose A1
  • HY-N6076
    Tenuifoliside A 139726-35-5 98.09%
    Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells.
    Tenuifoliside A
  • HY-N2498
    Glomeratose A 202471-84-9 99.89%
    Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia.
    Glomeratose A
  • HY-N1407
    Polygalaxanthone III 162857-78-5 99.28%
    Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC50 of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage.
    Polygalaxanthone III
  • HY-N0801
    Polygalacic acid 22338-71-2 98.92%
    Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.
    Polygalacic acid
  • HY-N4268
    Tenuifoliside B 139726-36-6 99.21%
    Tenuifoliside B, a component isolated from Polygalae Radix, inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. Tenuifoliside B shows potential cognitive improvement and cerebral protective effects. Tenuifoliside B has potential to become an anti-AD lead compound.
    Tenuifoliside B