1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. Tenuifoliside A

Tenuifoliside A 

Cat. No.: HY-N6076
Handling Instructions

Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells.

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Tenuifoliside A Chemical Structure

Tenuifoliside A Chemical Structure

CAS No. : 139726-35-5

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Description

Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells[1].

In Vitro

Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viability significantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect[1].
Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126[1].

Molecular Weight

682.62

Formula

C₃₁H₃₈O₁₇

CAS No.

139726-35-5

SMILES

OC[[email protected]@]1([[email protected]]([[email protected]](O)[[email protected]@H](CO)O1)OC(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)O[[email protected]@H]3O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]3O)COC(C4=CC=C(O)C=C4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Tenuifoliside AERKExtracellular signal regulated kinasesC6cellsanti-apoptoticantidepressant-like,neneurotrophicInhibitorinhibitorinhibit

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