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Basement Membrane Matrix

25 Cited Publications
Customer Review

Based on 25 publication(s) in Google Scholar

MCE Basement Membrane Matrix is primarily composed of natural basement membrane matrix extracted from mouse tumors.This product is mainly used for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.

  • Storage :
    -20°C, 2 years. Avoid repeated freezing and thawing. Shipping with dry ice.
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Basement Membrane Matrix Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Description & Advantages

MCE Basement Membrane Matrix is a natural basement membrane matrix extracted from mouse tumors and is composed mainly of various growth factors and extracellular matrix components. The main extracellular matrix components are: Laminin, Col-IV, Entactin, Heparan sulphate proteoglycans, etc. The main growth factor components are: insulin-like growth factor (IGF-1), transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (bFGF), etc. The concentration of each component in MCE basement membrane matrix conforms to the standard type range.

MCE Basement Membrane Matrix is suitable for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.

Protocol

Recommended Application Methods

Application Method Primary Function Common Applications
Thin Gel Forms an approximately 0.5 mm gel layer Primary cell culture, cell migration and invasion assays
Thin Coating Does not form a gel; forms an ECM coating layer only Primary cell culture, iPSC culture, and cell adhesion assays
Thick Gel Forms a 1-2 mm three-dimensional gel structure Angiogenesis assays and aortic ring assays
Gel Embedding Cells are completely embedded within the matrix Organoid culture and tumor spheroid invasion assays

Preparation Before Experiment

• Slight variations in protein concentration may occur between different batches. Please refer to the corresponding Certificate of Analysis (COA) for specific information.

• To achieve optimal experimental reproducibility, it is recommended to calculate the required volume based on the actual protein concentration and dilute the matrix using pre-chilled serum-free medium.

• Maintain low temperature conditions (ice bath or 4°C) throughout the entire procedure to prevent premature gelation of the basement membrane matrix.

Storage

-20°C, 2 years.

Avoid repeated freezing and thawing.

Shipping with dry ice.

Components

Components HY-K6002-1 mL HY-K6002-5 mL HY-K6002-10 mL
Basement Membrane Matrix 1 mL 5 mL 10 mL

Documentation

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100 mg

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Assay Types
  • Experimental Validation Results for Basement Membrane Matrix
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    MedChemExpress Validation
    Cell type: HUVECs (immortalized cell line, mixed with primary cells at passages P10-P18)
    Seeding density: 8,000 cells/well (1.6 × 105 cells/mL)
    Matrix gel: 8 μL
    Complete culture medium: 50 μL
    Under identical tube formation assay conditions, MCE matrix gel (Basement Membrane Matrix, HY-K6002) demonstrated superior tube-forming performance compared with competitor brands at both undiluted and 2:1 dilution conditions. The tubular structures formed with MCE matrix gel were more complete and continuous, with clearer and more stable network architecture.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    MedChemExpress Validation
    Cell type: HUVECs (immortalized cell line, mixed with primary cells at passages P10-P18)
    Seeding density: 8,000 cells/well (1.6 × 105 cells/mL)
    Matrix gel: 8 μL
    Complete culture medium: 50 μL
    Under identical tube formation assay conditions, the tube-forming performance of MCE matrix gel (Basement Membrane Matrix, HY-K6002) and competitor brands was compared at both undiluted and 2:1 dilution conditions. The tube-forming capacity of different production batches of MCE matrix gel was consistent, with complete and continuous tubular structures and clear, stable network architecture. The overall tube formation performance was stable and reproducible, with minimal batch-to-batch variation, demonstrating good batch consistency.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    MedChemExpress Validation
    MCE Basement Membrane Matrix (HY-K6002) supported cell invasion at a level comparable to that of the competitor matrix.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    MedChemExpress Validation
    MCE Basement Membrane Matrix (HY-K6002) supported cell invasion at a level comparable to that of the competitor matrix.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    MedChemExpress Validation
    Under identical tube formation assay conditions, the tube-forming performance of MCE matrix gel (Basement Membrane Matrix, HY-K6002) and competitor brands was compared at both undiluted and 2:1 dilution conditions. The tube-forming capacity of different production batches of MCE matrix gel was consistent, with complete and continuous tubular structures and clear, stable network architecture. The overall tube formation performance was stable and reproducible, with minimal batch-to-batch variation, demonstrating good batch consistency.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    Basement Membrane Matrix purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Aug 15:494:138736. [Abstract]

    Representative images: thHTR8/SVneo cells were treated with different concentrations of NaAsO2 (0.02, 0.2, 2 μM) for 12 days.

  • Experimental Validation Results for Basement Membrane Matrix
    1/16

    Basement Membrane Matrix purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]

    Tube formation capacity was assessed by tube formation assay after ox-LDL treatment.

  • Basement Membrane Matrix Product Image
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  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Experimental Validation Results for Basement Membrane Matrix
  • Basement Membrane Matrix Product Image