1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF superfamily
  4. Epigen

Epigen is a member of the epidermal growth factor the (EGF) superfamily that is the latest addition to the family of mammalian EGFR ligands. Epigen shows 24-37% identity to members of the EGF superfamily including EGF, transforming growth factor α (TGF-α), and Epiregulin. It is a mitogenic with ability to promote the growth of epithelial cells. Epigen is encoded by the EPGN gene. The precursor of EPG is a widely expressed transmembrane glycoprotein that undergoes cleavage at two sites to release a soluble EGF-like domain. Despite low affinity binding to EGFR, sub-maximal receptor activation by Epigen delivers strong mitogenic signals. Similarly to the other EGFR ligands, the expression of epigen is up-regulated by hormones and in certain cancer types.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7010
    Epigen Protein, Human

    rHuEpigen; Epithelial mitogen; EPG

    Human E. coli
    Epigen Protein, Human is a EGF-like growth factor that does not stimulate cells singly expressing ErbB-2, but acts as a mitogen for cells expressing ErbB-1 and co-expressing ErbB-2 in combination with the other ErbBs, with potent mitogenic activity.
  • HY-P7010A
    Epigen Protein, Human (CHO)

    rHuEpigen; Epithelial mitogen; EPG

    Human CHO
    Epigen Protein, Human (CHO) is a EGF-like growth factor that does not stimulate cells singly expressing ErbB-2, but acts as a mitogen for cells expressing ErbB-1 and co-expressing ErbB-2 in combination with the other ErbBs, with potent mitogenic activity.
Cat. No. Product Name Effect Purity