Epigen
Epigen is a member of the epidermal growth factor the (EGF) superfamily that is the latest addition to the family of mammalian EGFR ligands. Epigen shows 24-37% identity to members of the EGF superfamily including EGF, transforming growth factor α (TGF-α), and Epiregulin. It is a mitogenic with ability to promote the growth of epithelial cells. Epigen is encoded by the EPGN gene. The precursor of EPG is a widely expressed transmembrane glycoprotein that undergoes cleavage at two sites to release a soluble EGF-like domain.
Despite low affinity binding to EGFR, sub-maximal receptor activation by Epigen delivers strong mitogenic signals. Similarly to the other EGFR ligands, the expression of epigen is up-regulated by hormones and in certain cancer types.
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Epigen Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
