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Classic FDA-Approved Drug Library

83 Cited Publications
Customer Review

Based on 83 publication(s) in Google Scholar

MCE Classic FDA-Approved Drug Library features a curated selection of marketed drugs that have achieved the highest prescription volumes and greatest clinical impact in global practice since 2006. The collection covers eight major therapeutic areas, including cardiovascular diseases, oncology, metabolic disorders, infectious diseases, central nervous system disorders, respiratory diseases, digestive system diseases, and immunological conditions. All compounds have been validated through long‑term clinical use and possess well‑defined molecular targets, well‑established pharmacokinetic properties, quantifiable efficacy endpoints, and comprehensive toxicological safety profiles.

The library currently contains 169 representative drugs and is designed to serve as an efficient tool for drug repurposing, phenotypic screening, mechanism‑of‑action studies, and combination therapy strategy development.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Virtual Screening
Cell-based Compound Screening
Affinity Mass Spectrometry Drug Screening
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Compound Screening Libraries

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Description & Advantages

•   A unique collection of 169 compounds.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 169 compounds supplied as pre-dissolved Solutions or Solid.

Solution: 160 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage
-80°C
Shipping
Blue ice or dry ice

Documentation

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Composition

Autophagy (32)

Apoptosis (27)

Bacterial (17)

HIV (16)

Antibiotic (11)

Adrenergic Receptor (8)

SARS-CoV (8)

Reverse Transcriptase (7)

VEGFR (7)

5-HT Receptor (6)

Dopamine Receptor (6)

PDGFR (6)

Bcr-Abl (5)

Cytochrome P450 (5)

HIV Integrase (5)

Androgen Receptor (4)

Beta-lactamase (4)

Btk (4)

c-Kit (4)

Calcium Channel (4)

CFTR (4)

Endogenous Metabolite (4)

Factor Xa (4)

FGFR (4)

Glucocorticoid Receptor (4)

HCV (4)

JAK (4)

Keap1-Nrf2 (4)

Mitophagy (4)

ADC Payloads (3)

CDK (3)

Dipeptidyl Peptidase (3)

Ferroptosis (3)

mAChR (3)

MEK (3)

Molecular Glues (3)

Parasite (3)

Phosphodiesterase (PDE) (3)

Prostaglandin Receptor (3)

Raf (3)

RET (3)

Src (3)

Akt (2)

AMPK (2)

Angiotensin Receptor (2)

Bcl-2 Family (2)

CGRP Receptor (2)

Complement System (2)

DNA/RNA Synthesis (2)

EGFR (2)

ERK (2)

FLT3 (2)

Fungal (2)

GABA Receptor (2)

HBV (2)

HIV Protease (2)

HMG-CoA Reductase (HMGCR) (2)

Ligands for E3 Ligase (2)

Ligands for Target Protein for PROTAC (2)

Nucleoside Antimetabolite/Analog (2)

P2Y Receptor (2)

PARP (2)

PI3K (2)

Proton Pump (2)

Reactive Oxygen Species (ROS) (2)

Serotonin Transporter (2)

SGLT (2)

Sodium Channel (2)

TAM Receptor (2)

Thrombin (2)

Thrombopoietin Receptor (2)

Thymidylate Synthase (2)

Anaplastic lymphoma kinase (ALK) (1)

Aryl Hydrocarbon Receptor (1)

ATP Citrate Lyase (1)

c-Met/HGFR (1)

Caspase (1)

Chloride Channel (1)

CMV (1)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1)

Endothelin Receptor (1)

Enterovirus (1)

Environmental Pollutants (1)

Estrogen Receptor/ERR (1)

Exosomes (1)

FKBP (1)

GLP Receptor (1)

Glucosylceramide Synthase (GCS) (1)

GnRH Receptor (1)

Guanylate Cyclase (1)

HCV Protease (1)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (1)

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