Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
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Beta-lactamase 관련 제품 (257)
관련 제품 (257)
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Beta-lactamase Isoform Comparison
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Avibactam sodium
0 ImagesSynonyms: NXL-104; AVE1330AAvibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
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Ceftazidime
0 ImagesSynonyms: GR20263Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
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Tubastatin A
0 ImagesTubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
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Vaborbactam
0 ImagesSynonyms: RPX7009Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.
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Cefpiramide sodium
0 ImagesSynonyms: SM-1652; Wy-44635Cefpiramide sodium (SM-1652) is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide sodium shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide sodium is moderately susceptible to β-lactamase.
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Sulbactam pivoxil
0 ImagesSynonyms: Pivsulbactam; CP 47904
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Piperacillin (Standard)
0 ImagesCat. No.: HY-B1923RCAS No.: 61477-96-1Synonyms: Pipracil (Standard)Piperacillin (Standard) is the analytical standard of Piperacillin. This product is intended for research and analytical applications. Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam.
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Relebactam
0 ImagesSynonyms: MK-7655Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.
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Nitrocefin
0 ImagesNitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics.
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Tubacin
0 ImagesTubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
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Taniborbactam hydrochloride
0 ImagesSynonyms: VNRX-5133 hydrochlorideTaniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria.
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Cefotaxime
0 ImagesSynonyms: Cefotaxim; HR-756Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
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Zidebactam
0 ImagesSynonyms: WCK-5107Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL.
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Tubastatin A Hydrochloride
0 ImagesSynonyms: Tubastatin A HCl; TSA HClTubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
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Eravacycline dihydrochloride
0 ImagesSynonyms: TP-434 dihydrochloride; TP-434-046Eravacycline dihydrochloride (TP-434 dihydrochloride) is a potent and broad-spectrum antibacterial agent.
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Penicillin G sodium salt
0 ImagesPenicillin G sodium salt is a typical β-lactam antibiotic.
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Cefoxitin
0 ImagesCefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
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Tazobactam
0 ImagesSynonyms: CL-298741; YTR-830HTazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
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Piperacillin
0 ImagesSynonyms: PipracilPiperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam.
