1. Anti-infection
  2. Bacterial

Vaborbactam (Synonyms: RPX7009)

Cat. No.: HY-19930 Purity: 99.85%
Handling Instructions

Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

For research use only. We do not sell to patients.

Vaborbactam Chemical Structure

Vaborbactam Chemical Structure

CAS No. : 1360457-46-0

Size Price Stock Quantity
10 mM * 1 mL in Water USD 431 In-stock
Estimated Time of Arrival: December 31
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

In Vitro

Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes[1]. Vaborbactam restores meropenem activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of meropenem-vaborbactam). Meropenem-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated meropenem MICs at ≤1 μg/mL[2]. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase[3].

In Vivo

Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects[3].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 5.26 mg/mL (17.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3654 mL 16.8271 mL 33.6542 mL
5 mM 0.6731 mL 3.3654 mL 6.7308 mL
10 mM 0.3365 mL 1.6827 mL 3.3654 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  108 mM sodium carbonate

    Solubility: 25 mg/mL (84.14 mM); Clear solution; Need ultrasonic

References
Molecular Weight

297.14

Formula

C₁₂H₁₆BNO₅S

CAS No.

1360457-46-0

SMILES

O=C(O)C[[email protected]@H]1CC[[email protected]](NC(CC2=CC=CS2)=O)B(O)O1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.85%

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Product Name:
Vaborbactam
Cat. No.:
HY-19930
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Vaborbactam

Cat. No.: HY-19930