2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Vaborbactam

Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

For research use only. We do not sell to patients.

CAS No. : 1360457-46-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 41 publication(s) in Google Scholar

Vaborbactam Related Antibodies

Top Publications Citing Use of Products

41 Publications Citing Use of MCE Vaborbactam

Bio/Physico-chemical Assay
Microbiological Assay

    Vaborbactam purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Sep 14;10(9):1110.  [Abstract]

    HEPES buffer or plasma samples spiked with 100 mg/L of meropenem, 100 mg/L of Vaborbactam or the mixture of them were subjected to the NDM-1 biosensor; the activity responses (mV) of the NDM-1 biosensor to each agent spiked in HEPES and the net activity response (∆mV) of the NDM-1 biosensor to each agent spiked in plasma are shown in panel.

    Vaborbactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2021 Nov;58(5):106439.  [Abstract]

    The β-lactamase L2 of S. maltophilia seemed overall the most susceptible to BLIs, with sulbactam and tazobactam lowering MICATM to 4–8 µg/mL, Vaborbactam (VAB; 0-32 μg/mL) to 2 µg/mL, and AVI and REL, the most effective BLIs, lowered MIC ATM to ≤1 µg/mL.

    Vaborbactam purchased from MedChemExpress. Usage Cited in: J Clin Microbiol. 2020 Aug 24;58(9):e00932-20.  [Abstract]

    100 μl of a Tris-HCl 20 mmol/liter lysis buffer containing 0.1 mM ZnSO4 and vaborbactam (50 μg/ml; MedChemExpress; reference no. HY-19930) in tube 5.A color change from yellow to red in tube 1 only containing water and the absence of any color change (no hydrolysis of nitrocefin) in the other tubes 2 to 5 indicate lack of carbapenemase activity but production of a noncarbapenemase β-lactamase, such as TEM-1 or CTX-M-type enzymes.

    View All Beta-lactamase Isoform Specific Products:

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    Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

    In Vitro

    Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes[1]. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL[2]. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Vaborbactam Related Antibodies
    In Vivo

    Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    297.14

    Formula

    C12H16BNO5S
    CAS No.
    Appearance

    Solid

    Color

    Light brown to yellow

    SMILES

    O=C(O)C[C@@H]1CC[C@H](NC(CC2=CC=CS2)=O)B(O)O1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 5.26 mg/mL (17.70 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3654 mL 16.8271 mL 33.6542 mL
    5 mM 0.6731 mL 3.3654 mL 6.7308 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  108 mM Sodium carbonate 中最大溶解度

      Solubility: 25 mg/mL (84.14 mM); Clear solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 2.62 mg/mL (8.82 mM); Clear solution

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 27.5 mg/mL (92.55 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.85%

    SDS (393 KB)

    COA (247 KB) HNMR (195 KB) LCMS (390 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.3654 mL 16.8271 mL 33.6542 mL 84.1354 mL
    5 mM 0.6731 mL 3.3654 mL 6.7308 mL 16.8271 mL
    10 mM 0.3365 mL 1.6827 mL 3.3654 mL 8.4135 mL
    15 mM 0.2244 mL 1.1218 mL 2.2436 mL 5.6090 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Vaborbactam Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vaborbactam1360457-46-0RPX7009RPX 7009RPX-7009Beta-lactamaseBacterialβ-lactamaseInhibitorinhibitorinhibit

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