Cathepsin C
Cathepsin C (CTSC), also called dipeptidyl peptidase I, is a lysosomal cysteine protease that excises N-terminal dipeptides from protein substrates, distinguishing it from most cathepsins, which act as endopeptidases. The enzyme functions in a chloride-dependent manner and assembles into a homotetramer that is essential for its activity. Its best-established physiological role is the maturation of immune-cell serine proteases, including neutrophil elastase, Cathepsin G, proteinase 3, and granzymes. Inactivating CTSC mutations underlie Papillon-Lefèvre syndrome, characterized by palmoplantar keratoderma and periodontitis, and consequently the protease has become a validated target for developing therapies against neutrophil-driven inflammatory diseases.
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Cathepsin C Recombinant Proteins (4)
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Inhibitors & Agonists (12)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
