IL-6R
Interleukin-6 receptor (IL-6R) is a receptor for IL-6, belonging to the type I cytokine receptor family, subfamily 3. IL-6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. IL-6R is a protein complex composed of this protein and the interleukin-6 signal transductor (IL6ST/GP130/IL6β). This receptor subunit is also shared by many other cytokines. Dysproduction of IL-6 and this receptor has been implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. In addition, IL-6Rα (IL-6RA) is the primary functional alpha subunit of the IL-6 receptor, which is also a component of other interleukin receptors. IL-6RA is a type I transmembrane glycoprotein that regulates the biological activity of IL-6 by forming a complex with CD130[1]. There are two isoforms of IL-6Rα, including mIL6R (long form) or sIL6R (short form). The sIL-6R membrane binds IL6R and subunit IL6ST, which activate regenerative and anti-inflammatory signals through IL-6 transduction signals and promote the pro-inflammatory properties of IL-6. Therefore, the hydrolysis of IL-6R is also known as exdomain shedding[2]. IL-6Rα is an IL-6 agonist and also involved in JAK/STAT, MAPK and Akt signaling pathways[2][3]. IL-6R also plays an important role in acute response and hematopoietic response[4]. However, the signal transduction of IL6 is limited, because IL-6RA is tissue specific and only expressed specifically in some cells of liver and immune system[5].
- [1]. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70. [Content Brief]
- [2]. Malemud, et al. Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases. Curr Pharmacol Rep 4, 358-366.
- [3]. Larsen JV, et al. SorLA in Interleukin-6 Signaling and Turnover. Mol Cell Biol. 2017 May 16;37(11):e00641-16. [Content Brief]
- [4]. Giannitrapani L, et al. Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma. Ann N Y Acad Sci. 2002 Jun;963:46-52. [Content Brief]
- [5]. Arnold P, et al. Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles. Cells. 2020 May 24;9(5):1307. [Content Brief]
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IL-6R Recombinant Proteins (25)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
