MMP-1
MMP-1, historically called interstitial collagenase, is the archetype of the collagenase branch and initiates degradation of fibrillar type I, II and III collagen by cleaving the canonical Gly-Ile/Gly-Leu bond, which unwinds the triple helix. The enzyme is secreted as a zymogen by fibroblasts, keratinocytes, chondrocytes and many tumor cells, and its activity is tightly balanced by TIMPs. Beyond matrix turnover in wound repair, MMP-1 cleaves non-matrix substrates such as protease-activated receptor 1, linking proteolysis to platelet and inflammatory signaling. A common promoter single-nucleotide polymorphism (1G/2G) modulates transcription and has been associated with susceptibility to several cancers and periodontal disease.
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MMP-1 Recombinant Proteins (2)
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Inhibitors & Agonists (67)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
