1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HIV Integrase

HIV Integrase

HIV Integrase is an enzyme produced by a HIV that enables its genetic material to be integrated into the DNA of the infected cell. IN is a key component in the retroviral pre-integration complex (PIC). All retroviral integrase proteins contain three canonical domains, connected by flexible linkers: an N-terminal HH-CC zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.

HIV Integrase Related Products (19):

Cat. No. Product Name Effect Purity
  • HY-13238
    Dolutegravir Inhibitor 99.95%
    Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
  • HY-17605
    Bictegravir Inhibitor 99.88%
    Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • HY-10353
    Raltegravir Inhibitor 98.11%
    Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir potassium salt (MK 0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-107485
    HIV-1 integrase inhibitor 8 Inhibitor
    HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
  • HY-13238A
    Dolutegravir sodium Inhibitor 99.96%
    Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
  • HY-15592
    Cabotegravir Inhibitor 99.85%
    Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection.
  • HY-18601
    (±)-BI-D Inhibitor
    (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.
  • HY-18595
    BI 224436 Inhibitor 98.17%
    BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
  • HY-13269
    BMS-707035 Inhibitor 99.95%
    BMS-707035 is an HIV-1 integrase (IN) inhibitor with an IC50 value of 15 nM.
  • HY-N0457A
    L-Chicoric Acid Inhibitor 99.98%
    L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.
  • HY-B1408
    Salicylanilide Inhibitor 99.60%
    Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
  • HY-10522
    HIV-1 integrase inhibitor 2 Inhibitor 99.41%
    HIV-1 integrase inhibitor 2, in the treatment of human immunodeficiency virus (HIV) infection.
  • HY-13025
    HIV-1 integrase inhibitor Inhibitor 98.64%
    HIV-1 integrase inhibitor is uesful for anti-HIV.
  • HY-108820
    HIV-1 integrase inhibitor 4 Inhibitor
    HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
  • HY-108817
    HIV-1 integrase inhibitor 3 Inhibitor
    HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
  • HY-130760
    HIV-1 integrase inhibitor 7 Inhibitor
    HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC50 of 33.3 nM.
  • HY-N6711
    Equisetin Inhibitor
    Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537. Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity. Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria. Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.