1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HIV Integrase

HIV Integrase

HIV Integrase is an enzyme produced by a HIV that enables its genetic material to be integrated into the DNA of the infected cell. IN is a key component in the retroviral pre-integration complex (PIC). All retroviral integrase proteins contain three canonical domains, connected by flexible linkers: an N-terminal HH-CC zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.

HIV Integrase Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-13238
    Dolutegravir Inhibitor 99.95%
    Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) with an IC50 of 2.7 nM.
  • HY-17605
    Bictegravir Inhibitor 98.27%
    Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-15310
    Ivermectin Inhibitor >98.0%
    Ivermectin (MK-933) is a broad-spectrum anti-parasite medication used in humans most commonly to treat nematode infections such as onchocerciasis, as well as scabies and lice. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs).
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • HY-N6711
    Equisetin Inhibitor
    Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537. Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity. Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria. Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections.
  • HY-15592
    Cabotegravir Inhibitor 99.85%
    Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM).
  • HY-13238A
    Dolutegravir sodium Inhibitor
    Dolutegravir sodium is an inhibitor of HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • HY-18595
    BI 224436 Inhibitor 98.17%
    BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
  • HY-18601
    (±)-BI-D Inhibitor
    (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.
  • HY-10353
    Raltegravir Inhibitor 98.11%
    Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-13269
    BMS-707035 Inhibitor 99.95%
    BMS-707035 is an HIV-1 integrase (IN) inhibitor with an IC50 value of 15 nM.
  • HY-13025
    HIV-1 integrase inhibitor Inhibitor 98.64%
    HIV-1 integrase inhibitor is uesful for anti-HIV.
  • HY-13305
    MK-2048 Inhibitor >98.0%
    MK-2048 is a potent inhibitor of integrase and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
  • HY-10522
    HIV-1 integrase inhibitor 2 Inhibitor 99.41%
    HIV-1 integrase inhibitor 2, in the treatment of human immunodeficiency virus (HIV) infection.
  • HY-B1408
    Salicylanilide Inhibitor 99.60%
    Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
  • HY-108820
    HIV-1 integrase inhibitor 4 Inhibitor
    HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.
  • HY-108817
    HIV-1 integrase inhibitor 3 Inhibitor
    HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
Isoform Specific Products

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